This article presents a simplified method for preparing a lead citrate stain, commonly used in electron microscopy, to reduce the time and complexity of the traditional Reynolds' stain preparation. The new method involves using commercially available lead citrate mixed with concentrated sodium hydroxide to form a stain that provides equal contrast and delicacy to the traditional stain. The preparation process is quick and easy, taking less than 5 minutes. The authors provide detailed instructions for preparing the stain, including tips to prevent the formation of precipitates and optimize staining times. They also offer guidance on troubleshooting common issues and maintaining the quality of the stain. The method has been successfully used in their laboratory for approximately one year, staining both vertebrate and invertebrate tissues.This article presents a simplified method for preparing a lead citrate stain, commonly used in electron microscopy, to reduce the time and complexity of the traditional Reynolds' stain preparation. The new method involves using commercially available lead citrate mixed with concentrated sodium hydroxide to form a stain that provides equal contrast and delicacy to the traditional stain. The preparation process is quick and easy, taking less than 5 minutes. The authors provide detailed instructions for preparing the stain, including tips to prevent the formation of precipitates and optimize staining times. They also offer guidance on troubleshooting common issues and maintaining the quality of the stain. The method has been successfully used in their laboratory for approximately one year, staining both vertebrate and invertebrate tissues.