A study was conducted to evaluate psychological distress and self-esteem among patients undergoing hemodialysis. The study involved 30 patients, selected through convenient sampling. The results showed that 36.7% of the participants were doing well, 23.3% had mild psychological distress, 23.3% had moderate distress, and 16.7% had severe distress. Regarding self-esteem, 73.3% had normal self-esteem, 20% had low self-esteem, and 6.7% had above average self-esteem. A significant relationship was found between social and family support and self-esteem (p=0.033). Chronic kidney disease (CKD) is a progressive condition affecting over 800 million people globally, with hemodialysis being the most common treatment. The study highlights the psychological challenges faced by dialysis patients, including emotional and physical difficulties. Psychological distress refers to unpleasant feelings that can interfere with daily life, while self-esteem reflects a person's satisfaction with their life and positive self-image. The study found that about half of the participants experienced psychological distress, with 16.7% having severe distress. Most participants (73.3%) had normal self-esteem, while 27% had low or average self-esteem. The study also found that social and family support significantly influenced self-esteem. The study recommends replicating the research with larger samples and conducting experimental studies to reduce psychological distress and improve self-esteem among dialysis patients. The findings emphasize the importance of addressing psychological and social factors in the care of hemodialysis patients.A study was conducted to evaluate psychological distress and self-esteem among patients undergoing hemodialysis. The study involved 30 patients, selected through convenient sampling. The results showed that 36.7% of the participants were doing well, 23.3% had mild psychological distress, 23.3% had moderate distress, and 16.7% had severe distress. Regarding self-esteem, 73.3% had normal self-esteem, 20% had low self-esteem, and 6.7% had above average self-esteem. A significant relationship was found between social and family support and self-esteem (p=0.033). Chronic kidney disease (CKD) is a progressive condition affecting over 800 million people globally, with hemodialysis being the most common treatment. The study highlights the psychological challenges faced by dialysis patients, including emotional and physical difficulties. Psychological distress refers to unpleasant feelings that can interfere with daily life, while self-esteem reflects a person's satisfaction with their life and positive self-image. The study found that about half of the participants experienced psychological distress, with 16.7% having severe distress. Most participants (73.3%) had normal self-esteem, while 27% had low or average self-esteem. The study also found that social and family support significantly influenced self-esteem. The study recommends replicating the research with larger samples and conducting experimental studies to reduce psychological distress and improve self-esteem among dialysis patients. The findings emphasize the importance of addressing psychological and social factors in the care of hemodialysis patients.