This systematic review examines the classification and functionalities of smartphone-based healthcare technologies as discussed in academic literature. The study searched MEDLINE for articles on the design, development, evaluation, or use of smartphone software for healthcare professionals, medical or nursing students, and patients. A total of 55 articles discussing 83 applications were selected. The applications were categorized into three groups: healthcare professionals (57 applications), medical or nursing students (11 applications), and patients (15 applications). The most useful applications for healthcare professionals and medical or nursing students were disease diagnosis, drug reference, and medical calculator applications. The review highlights the growing adoption of smartphones in healthcare, their role in improving clinical communication, access to information systems, and patient education and self-management. The study also discusses the distribution of applications across major smartphone operating systems, with iOS being the most popular platform for healthcare applications.This systematic review examines the classification and functionalities of smartphone-based healthcare technologies as discussed in academic literature. The study searched MEDLINE for articles on the design, development, evaluation, or use of smartphone software for healthcare professionals, medical or nursing students, and patients. A total of 55 articles discussing 83 applications were selected. The applications were categorized into three groups: healthcare professionals (57 applications), medical or nursing students (11 applications), and patients (15 applications). The most useful applications for healthcare professionals and medical or nursing students were disease diagnosis, drug reference, and medical calculator applications. The review highlights the growing adoption of smartphones in healthcare, their role in improving clinical communication, access to information systems, and patient education and self-management. The study also discusses the distribution of applications across major smartphone operating systems, with iOS being the most popular platform for healthcare applications.