This systematic review examines the epidemiology of ankle injuries and sprains in sports, covering studies from 1977 to 2005. The review includes 227 studies from 38 countries, reporting on 70 sports and a total of 201,600 injury cases, with 32,509 ankle injuries. Ankle injuries were the most common in 24 of the 70 sports, particularly in aeroball, wall climbing, indoor volleyball, mountaineering, netball, and field events. Ankle sprains were the most common type of ankle injury in 33 of the 43 sports, including Australian football, field hockey, handball, orienteering, scooter, and squash. The review also found that ankle injuries and sprains were more prevalent in court games and team sports, such as rugby, soccer, volleyball, handball, basketball, and American football. The incidence of ankle injuries and sprains was highest in court games and team sports, with rugby, soccer, and volleyball showing the highest rates. The study provides a comprehensive overview of the epidemiology of ankle injuries and sprains in sports, which can help sports medicine specialists identify patterns and target future research and injury prevention efforts.This systematic review examines the epidemiology of ankle injuries and sprains in sports, covering studies from 1977 to 2005. The review includes 227 studies from 38 countries, reporting on 70 sports and a total of 201,600 injury cases, with 32,509 ankle injuries. Ankle injuries were the most common in 24 of the 70 sports, particularly in aeroball, wall climbing, indoor volleyball, mountaineering, netball, and field events. Ankle sprains were the most common type of ankle injury in 33 of the 43 sports, including Australian football, field hockey, handball, orienteering, scooter, and squash. The review also found that ankle injuries and sprains were more prevalent in court games and team sports, such as rugby, soccer, volleyball, handball, basketball, and American football. The incidence of ankle injuries and sprains was highest in court games and team sports, with rugby, soccer, and volleyball showing the highest rates. The study provides a comprehensive overview of the epidemiology of ankle injuries and sprains in sports, which can help sports medicine specialists identify patterns and target future research and injury prevention efforts.