This systematic review analyzed 227 studies on ankle injuries and sprains in 70 sports across 38 countries, covering a time span from 1977 to 2005. The total number of injury cases was 201,600, with 32,509 ankle injuries and 11,847 ankle sprains. Ankle injuries were the most common in 24 sports, including aeroball, wall climbing, indoor volleyball, mountaineering, netball, and track and field events. Ankle sprains were the most common type of ankle injury in 33 sports, including Australian football, field hockey, handball, orienteering, scooter, and squash. Ankle sprains accounted for 77% of all ankle injuries, with 73% involving the anterior talofibular ligament. Ankle injuries and sprains were most prevalent in court games and team sports such as rugby, soccer, volleyball, handball, basketball, and lacrosse. The knee was the second most common injured body site after the ankle. The study highlights the importance of injury prevention strategies in sports, particularly for high-risk activities. The findings provide a comprehensive overview of ankle injury epidemiology in sports, aiding sports medicine specialists in identifying injury patterns and implementing prevention measures. The study also notes the limitations of the data, including language barriers and regional disparities in research. Overall, the review emphasizes the need for targeted injury prevention in sports with high ankle injury rates.This systematic review analyzed 227 studies on ankle injuries and sprains in 70 sports across 38 countries, covering a time span from 1977 to 2005. The total number of injury cases was 201,600, with 32,509 ankle injuries and 11,847 ankle sprains. Ankle injuries were the most common in 24 sports, including aeroball, wall climbing, indoor volleyball, mountaineering, netball, and track and field events. Ankle sprains were the most common type of ankle injury in 33 sports, including Australian football, field hockey, handball, orienteering, scooter, and squash. Ankle sprains accounted for 77% of all ankle injuries, with 73% involving the anterior talofibular ligament. Ankle injuries and sprains were most prevalent in court games and team sports such as rugby, soccer, volleyball, handball, basketball, and lacrosse. The knee was the second most common injured body site after the ankle. The study highlights the importance of injury prevention strategies in sports, particularly for high-risk activities. The findings provide a comprehensive overview of ankle injury epidemiology in sports, aiding sports medicine specialists in identifying injury patterns and implementing prevention measures. The study also notes the limitations of the data, including language barriers and regional disparities in research. Overall, the review emphasizes the need for targeted injury prevention in sports with high ankle injury rates.