Responsible Research and Innovation (RRI) is a strategy for stakeholders to be mutually responsive to each other and anticipate research and innovation outcomes related to the grand challenges of our time. RRI aims to ensure that research and innovation processes are more responsive and adaptive to these challenges, including the introduction of broader foresight and impact assessments for new technologies beyond their anticipated market benefits and risks. The chapter outlines a vision of RRI, provides a definition of the concept, and proposes a framework for its implementation. The concept of RRI is not clearly defined, and approaches to its implementation may vary. However, RRI should be understood as a strategy where stakeholders consider the ethical acceptability, sustainability, and societal desirability of the innovation process and its marketable products. This involves a product dimension, where products are evaluated and designed with a view to their normative anchor points, such as environmental protection, human health, sustainability, and societal desirability. A process dimension reflects deliberative democracy, involving stakeholders and other interested parties in an inclusive innovation process. The chapter discusses examples of irresponsible innovation, such as the introduction of genetically modified soya in the EU, the failure of an electronic patient record system in the Netherlands, and the introduction of body scanners at airports. These examples highlight the need for stakeholders to share co-responsibility for innovation trajectories and to address the ethical, social, and environmental impacts of technologies. The chapter also discusses the application of the precautionary principle, which is embedded in EU law and applies especially within EU product authorization procedures. The precautionary principle works as an incentive to make safe and sustainable products and allows governmental bodies to intervene with risk management decisions when necessary. Innovation governance involves multistakeholder involvement, the use of codes of conduct, and the establishment of proactive scientific communities. These mechanisms help to identify risks and benefits at an early stage, direct research funds towards societal objectives, and ensure that innovation is responsible and sustainable. The chapter concludes that RRI requires a framework that addresses the ethical, social, and environmental impacts of technologies, promotes sustainable development, and ensures that innovation is responsive to societal needs. This framework is based on the normative anchor points of the Treaty on the European Union and includes mechanisms such as technology assessment and foresight, the application of the precautionary principle, and innovation governance.Responsible Research and Innovation (RRI) is a strategy for stakeholders to be mutually responsive to each other and anticipate research and innovation outcomes related to the grand challenges of our time. RRI aims to ensure that research and innovation processes are more responsive and adaptive to these challenges, including the introduction of broader foresight and impact assessments for new technologies beyond their anticipated market benefits and risks. The chapter outlines a vision of RRI, provides a definition of the concept, and proposes a framework for its implementation. The concept of RRI is not clearly defined, and approaches to its implementation may vary. However, RRI should be understood as a strategy where stakeholders consider the ethical acceptability, sustainability, and societal desirability of the innovation process and its marketable products. This involves a product dimension, where products are evaluated and designed with a view to their normative anchor points, such as environmental protection, human health, sustainability, and societal desirability. A process dimension reflects deliberative democracy, involving stakeholders and other interested parties in an inclusive innovation process. The chapter discusses examples of irresponsible innovation, such as the introduction of genetically modified soya in the EU, the failure of an electronic patient record system in the Netherlands, and the introduction of body scanners at airports. These examples highlight the need for stakeholders to share co-responsibility for innovation trajectories and to address the ethical, social, and environmental impacts of technologies. The chapter also discusses the application of the precautionary principle, which is embedded in EU law and applies especially within EU product authorization procedures. The precautionary principle works as an incentive to make safe and sustainable products and allows governmental bodies to intervene with risk management decisions when necessary. Innovation governance involves multistakeholder involvement, the use of codes of conduct, and the establishment of proactive scientific communities. These mechanisms help to identify risks and benefits at an early stage, direct research funds towards societal objectives, and ensure that innovation is responsible and sustainable. The chapter concludes that RRI requires a framework that addresses the ethical, social, and environmental impacts of technologies, promotes sustainable development, and ensures that innovation is responsive to societal needs. This framework is based on the normative anchor points of the Treaty on the European Union and includes mechanisms such as technology assessment and foresight, the application of the precautionary principle, and innovation governance.