A comprehensive pathway map of the epidermal growth factor receptor (EGFR) signaling pathway has been developed, revealing a bow-tie structure with multiple feedback loops. The map includes molecular interactions such as EGFR endocytosis, small GTPase signaling, MAPK cascade, PIP signaling, cell cycle, Ca²+ signaling, and GPCR-mediated EGFR transactivation. It was created using CellDesigner software and stored in Systems Biology Markup Language (SBML), enabling computational analysis. The map is based on 242 scientific papers and includes 211 reactions and 322 species, such as proteins, ions, simple molecules, oligomers, genes, and RNAs. The map highlights the architecture of the signaling network, showing how various ligands bind to ErbB receptors, leading to a convergence of signals into a few molecules that activate cascades. The map also includes feedback loops, such as positive and negative feedback, and inhibitory feed-forward paths, which regulate the signaling network. The EGFR signaling pathway is part of a larger network with complex interactions, including crosstalk between ErbB and GPCR signaling. The map provides a detailed representation of the signaling network, including the roles of various proteins and enzymes in the pathway. It also includes graphical notations for molecular interactions and modifications, allowing for clear visualization of the pathway. The map is a valuable resource for understanding the dynamics of EGFR signaling and its role in cellular processes such as growth, survival, and differentiation. The map is continuously updated and expanded based on new research findings.A comprehensive pathway map of the epidermal growth factor receptor (EGFR) signaling pathway has been developed, revealing a bow-tie structure with multiple feedback loops. The map includes molecular interactions such as EGFR endocytosis, small GTPase signaling, MAPK cascade, PIP signaling, cell cycle, Ca²+ signaling, and GPCR-mediated EGFR transactivation. It was created using CellDesigner software and stored in Systems Biology Markup Language (SBML), enabling computational analysis. The map is based on 242 scientific papers and includes 211 reactions and 322 species, such as proteins, ions, simple molecules, oligomers, genes, and RNAs. The map highlights the architecture of the signaling network, showing how various ligands bind to ErbB receptors, leading to a convergence of signals into a few molecules that activate cascades. The map also includes feedback loops, such as positive and negative feedback, and inhibitory feed-forward paths, which regulate the signaling network. The EGFR signaling pathway is part of a larger network with complex interactions, including crosstalk between ErbB and GPCR signaling. The map provides a detailed representation of the signaling network, including the roles of various proteins and enzymes in the pathway. It also includes graphical notations for molecular interactions and modifications, allowing for clear visualization of the pathway. The map is a valuable resource for understanding the dynamics of EGFR signaling and its role in cellular processes such as growth, survival, and differentiation. The map is continuously updated and expanded based on new research findings.