This paper presents a comprehensive pathway map of epidermal growth factor receptor (EGFR) signaling and related pathways. The map, created using CellDesigner software and stored in Systems Biology Markup Language (SBML), reveals that the overall architecture of the EGFR signaling system is a bow-tie (or hourglass) structure with several feedback loops. The map includes 211 reactions and 322 species, such as proteins, ions, simple molecules, oligomers, genes, and RNAs. The network is characterized by a bow-tie structure with diverse input pathways and feedback controls, which is a characteristic feature of robust evolvable systems. The paper also discusses the architectural features of the ErbB and GPCR signaling networks, the network control mechanisms, and the graphical notations used in the map. The authors plan to update and expand the map based on experimental data and community contributions.This paper presents a comprehensive pathway map of epidermal growth factor receptor (EGFR) signaling and related pathways. The map, created using CellDesigner software and stored in Systems Biology Markup Language (SBML), reveals that the overall architecture of the EGFR signaling system is a bow-tie (or hourglass) structure with several feedback loops. The map includes 211 reactions and 322 species, such as proteins, ions, simple molecules, oligomers, genes, and RNAs. The network is characterized by a bow-tie structure with diverse input pathways and feedback controls, which is a characteristic feature of robust evolvable systems. The paper also discusses the architectural features of the ErbB and GPCR signaling networks, the network control mechanisms, and the graphical notations used in the map. The authors plan to update and expand the map based on experimental data and community contributions.