The University of Wisconsin Genetics Computer Group (UWGCC) has developed a comprehensive set of sequence analysis programs for the Digital Equipment Corporation VAX computer using the VMS operating system. These programs, written in Fortran 77, are designed to interact with each other and can be used independently or in combination to solve complex problems. The software includes tools for sequence comparisons, mapping and searching, secondary structure analysis, composition analysis, sequence manipulation, and publication. The programs are user-friendly, interactive, and can handle both nucleic acid and protein sequences. UWGCC aims to make its software available at a low cost to scientists, with a fee of $2,000 for non-profit institutions and $4,000 for industries. The software is distributed on a 9-track magnetic tape and requires a VAX/VMS system with a tape drive. Inquiries can be directed to John Devereux at the University of Wisconsin.The University of Wisconsin Genetics Computer Group (UWGCC) has developed a comprehensive set of sequence analysis programs for the Digital Equipment Corporation VAX computer using the VMS operating system. These programs, written in Fortran 77, are designed to interact with each other and can be used independently or in combination to solve complex problems. The software includes tools for sequence comparisons, mapping and searching, secondary structure analysis, composition analysis, sequence manipulation, and publication. The programs are user-friendly, interactive, and can handle both nucleic acid and protein sequences. UWGCC aims to make its software available at a low cost to scientists, with a fee of $2,000 for non-profit institutions and $4,000 for industries. The software is distributed on a 9-track magnetic tape and requires a VAX/VMS system with a tape drive. Inquiries can be directed to John Devereux at the University of Wisconsin.