The Human Microbiome Project (HMP) is a large-scale initiative funded by the National Institutes of Health (NIH) to study the microbiome, the collection of microorganisms living in and on the human body. The HMP has developed a framework for metagenomic research, generating a wide range of high-quality data and resources. These include metagenomic sequences from 5,177 microbial taxonomic profiles and over 3.5 terabases of sequence data, as well as reference genomes from approximately 800 human-associated strains. The HMP has also developed standardized protocols for processing and interpreting metagenomic data, enabling the scientific community to study the human microbiome in detail. The HMP has collected data from 242 healthy adults, sampled at 15 or 18 body sites up to three times, and has generated a comprehensive set of data including 16S rRNA gene sequences, whole-genome shotgun (WGS) sequences, and reference genome alignments. These data have been used to study the composition and function of the human microbiome, and to develop tools for analyzing microbial communities. The HMP has also developed a data analysis and coordination center (DACC) to manage and share these data, and has created a variety of resources, including reference genomes, sequencing protocols, and analytical tools. The HMP has also developed a set of protocols for 16S and WGS sequencing, including the use of the Roche-454 FLX Titanium platform. These protocols have been tested and refined to ensure consistency and accuracy in data generation. The HMP has also developed metagenomic assemblies and gene catalogs, which have been used to study the functional and genetic diversity of the human microbiome. These data have been used to identify new gene clusters and to compare the microbiome of different body sites. The HMP has also developed a comprehensive set of resources for the study of the human microbiome, including reference genomes, sequencing protocols, and analytical tools. These resources have been used to study the microbiome of various body sites, including the airways, skin, oral cavity, gut, and vagina. The HMP has also developed a set of tools for analyzing the functional and genetic diversity of the microbiome, including gene prediction, metabolic reconstruction, and functional annotation. The HMP has also developed a set of resources for the study of the human microbiome, including reference genomes, sequencing protocols, and analytical tools. These resources have been used to study the microbiome of various body sites, including the airways, skin, oral cavity, gut, and vagina. The HMP has also developed a set of tools for analyzing the functional and genetic diversity of the microbiome, including gene prediction, metabolic reconstruction, and functional annotation. The HMP has also developed a set of resources for the study of the human microbiome, including reference genomes, sequencing protocols, and analytical tools.The Human Microbiome Project (HMP) is a large-scale initiative funded by the National Institutes of Health (NIH) to study the microbiome, the collection of microorganisms living in and on the human body. The HMP has developed a framework for metagenomic research, generating a wide range of high-quality data and resources. These include metagenomic sequences from 5,177 microbial taxonomic profiles and over 3.5 terabases of sequence data, as well as reference genomes from approximately 800 human-associated strains. The HMP has also developed standardized protocols for processing and interpreting metagenomic data, enabling the scientific community to study the human microbiome in detail. The HMP has collected data from 242 healthy adults, sampled at 15 or 18 body sites up to three times, and has generated a comprehensive set of data including 16S rRNA gene sequences, whole-genome shotgun (WGS) sequences, and reference genome alignments. These data have been used to study the composition and function of the human microbiome, and to develop tools for analyzing microbial communities. The HMP has also developed a data analysis and coordination center (DACC) to manage and share these data, and has created a variety of resources, including reference genomes, sequencing protocols, and analytical tools. The HMP has also developed a set of protocols for 16S and WGS sequencing, including the use of the Roche-454 FLX Titanium platform. These protocols have been tested and refined to ensure consistency and accuracy in data generation. The HMP has also developed metagenomic assemblies and gene catalogs, which have been used to study the functional and genetic diversity of the human microbiome. These data have been used to identify new gene clusters and to compare the microbiome of different body sites. The HMP has also developed a comprehensive set of resources for the study of the human microbiome, including reference genomes, sequencing protocols, and analytical tools. These resources have been used to study the microbiome of various body sites, including the airways, skin, oral cavity, gut, and vagina. The HMP has also developed a set of tools for analyzing the functional and genetic diversity of the microbiome, including gene prediction, metabolic reconstruction, and functional annotation. The HMP has also developed a set of resources for the study of the human microbiome, including reference genomes, sequencing protocols, and analytical tools. These resources have been used to study the microbiome of various body sites, including the airways, skin, oral cavity, gut, and vagina. The HMP has also developed a set of tools for analyzing the functional and genetic diversity of the microbiome, including gene prediction, metabolic reconstruction, and functional annotation. The HMP has also developed a set of resources for the study of the human microbiome, including reference genomes, sequencing protocols, and analytical tools.