This article provides a comprehensive overview of chemokines and their receptors, highlighting their roles in immune and inflammatory responses. Chemokines are small, secreted proteins that signal through G protein-coupled chemokine receptors, primarily on leukocytes, to regulate cell migration. The article covers the structure and classification of chemokines, the interactions between chemokines and receptors, and the impact of post-translational modifications and extracellular matrix interactions on chemokine function. It also discusses the diverse biological functions of chemokines, including their roles in development, homeostasis, immune surveillance, and disease. The article emphasizes the complexity of the chemokine network and its involvement in various cellular processes, such as cell migration, proliferation, and differentiation. Additionally, it explores the therapeutic potential of targeting chemokine receptors in the treatment of immune and inflammatory diseases.This article provides a comprehensive overview of chemokines and their receptors, highlighting their roles in immune and inflammatory responses. Chemokines are small, secreted proteins that signal through G protein-coupled chemokine receptors, primarily on leukocytes, to regulate cell migration. The article covers the structure and classification of chemokines, the interactions between chemokines and receptors, and the impact of post-translational modifications and extracellular matrix interactions on chemokine function. It also discusses the diverse biological functions of chemokines, including their roles in development, homeostasis, immune surveillance, and disease. The article emphasizes the complexity of the chemokine network and its involvement in various cellular processes, such as cell migration, proliferation, and differentiation. Additionally, it explores the therapeutic potential of targeting chemokine receptors in the treatment of immune and inflammatory diseases.