This article provides a comprehensive overview of immunometabolism, the interplay between immune cell metabolism and immune function. It outlines six major metabolic pathways—glycolysis, the TCA cycle, the pentose phosphate pathway, fatty acid oxidation, fatty acid synthesis, and amino acid metabolism—and discusses their roles in immune cell responses. The text emphasizes how changes in these pathways directly influence immune cell function, particularly in T cells, macrophages, and dendritic cells. It highlights the importance of metabolic reprogramming in immunity, showing how metabolic shifts are crucial for immune cell activation, proliferation, and effector functions. The article also discusses how metabolic pathways are regulated by signaling molecules such as mTOR and AMPK, and how these pathways are interconnected, with shared inputs and outputs. It provides insights into how specific metabolic changes, such as increased glycolysis, are associated with inflammatory responses, while other pathways like fatty acid oxidation and synthesis are linked to anti-inflammatory or regulatory functions. The text also explores the roles of amino acid metabolism, including glutamine, arginine, and tryptophan, in immune cell function and how their metabolism influences immune responses. Overall, the article underscores the growing importance of immunometabolism in understanding immune processes and offers a roadmap for immunologists to integrate metabolic insights into their research.This article provides a comprehensive overview of immunometabolism, the interplay between immune cell metabolism and immune function. It outlines six major metabolic pathways—glycolysis, the TCA cycle, the pentose phosphate pathway, fatty acid oxidation, fatty acid synthesis, and amino acid metabolism—and discusses their roles in immune cell responses. The text emphasizes how changes in these pathways directly influence immune cell function, particularly in T cells, macrophages, and dendritic cells. It highlights the importance of metabolic reprogramming in immunity, showing how metabolic shifts are crucial for immune cell activation, proliferation, and effector functions. The article also discusses how metabolic pathways are regulated by signaling molecules such as mTOR and AMPK, and how these pathways are interconnected, with shared inputs and outputs. It provides insights into how specific metabolic changes, such as increased glycolysis, are associated with inflammatory responses, while other pathways like fatty acid oxidation and synthesis are linked to anti-inflammatory or regulatory functions. The text also explores the roles of amino acid metabolism, including glutamine, arginine, and tryptophan, in immune cell function and how their metabolism influences immune responses. Overall, the article underscores the growing importance of immunometabolism in understanding immune processes and offers a roadmap for immunologists to integrate metabolic insights into their research.