The PrISMa platform is a holistic system for accelerating sorbent-based carbon capture technologies. It integrates materials design, process optimization, techno-economic analysis, and life-cycle assessment (LCA) to evaluate the performance of carbon capture materials and processes. The platform assesses over 60 case studies across five global regions, comparing materials, process configurations, and locations to identify the most cost-effective and environmentally sustainable solutions. It provides insights into the molecular characteristics of top-performing sorbents and evaluates environmental impacts, co-benefits, and trade-offs. By uniting stakeholders early in the research process, PrISMa accelerates the development of carbon capture technologies, aiming for a net-zero world. The platform uses molecular simulations to predict the adsorption thermodynamics of flue gas components, such as CO₂, N₂, and H₂O, based on experimental data or crystal structures. These data are used to compute parameters like purity, recovery, productivity, and energy requirements in the process layer. The techno-economic analysis layer evaluates the economic and technical viability, while the LCA layer assesses environmental impacts over the plant's lifetime. The platform also includes a visualization tool that provides access to all KPIs for case studies and over 1,200 materials. PrISMa considers various stakeholders' perspectives, including environmental managers, investors, and CO₂ producers. It calculates 50 key performance indicators (KPIs) for each case study, highlighting the complexity of selecting an optimal material. The platform identifies top-performing materials for further study and allows for detailed process modeling and investigation. It also uses machine learning to screen a larger chemical design space, improving the efficiency of material discovery. The platform's holistic approach enables the identification of materials that perform well across multiple KPIs, including cost-effectiveness, environmental impact, and process efficiency. It also considers the impact of different process configurations, such as temperature vacuum swing adsorption (TVSA) and temperature swing adsorption (TSA), on CO₂ capture performance. The platform highlights the importance of managing moisture in flue gas to maintain cost competitiveness and provides insights into the environmental and economic impacts of different regions and technologies. Overall, the PrISMa platform offers a comprehensive framework for evaluating and advancing carbon capture technologies, integrating materials science, process engineering, and environmental assessment to accelerate the development of sustainable solutions for reducing CO₂ emissions.The PrISMa platform is a holistic system for accelerating sorbent-based carbon capture technologies. It integrates materials design, process optimization, techno-economic analysis, and life-cycle assessment (LCA) to evaluate the performance of carbon capture materials and processes. The platform assesses over 60 case studies across five global regions, comparing materials, process configurations, and locations to identify the most cost-effective and environmentally sustainable solutions. It provides insights into the molecular characteristics of top-performing sorbents and evaluates environmental impacts, co-benefits, and trade-offs. By uniting stakeholders early in the research process, PrISMa accelerates the development of carbon capture technologies, aiming for a net-zero world. The platform uses molecular simulations to predict the adsorption thermodynamics of flue gas components, such as CO₂, N₂, and H₂O, based on experimental data or crystal structures. These data are used to compute parameters like purity, recovery, productivity, and energy requirements in the process layer. The techno-economic analysis layer evaluates the economic and technical viability, while the LCA layer assesses environmental impacts over the plant's lifetime. The platform also includes a visualization tool that provides access to all KPIs for case studies and over 1,200 materials. PrISMa considers various stakeholders' perspectives, including environmental managers, investors, and CO₂ producers. It calculates 50 key performance indicators (KPIs) for each case study, highlighting the complexity of selecting an optimal material. The platform identifies top-performing materials for further study and allows for detailed process modeling and investigation. It also uses machine learning to screen a larger chemical design space, improving the efficiency of material discovery. The platform's holistic approach enables the identification of materials that perform well across multiple KPIs, including cost-effectiveness, environmental impact, and process efficiency. It also considers the impact of different process configurations, such as temperature vacuum swing adsorption (TVSA) and temperature swing adsorption (TSA), on CO₂ capture performance. The platform highlights the importance of managing moisture in flue gas to maintain cost competitiveness and provides insights into the environmental and economic impacts of different regions and technologies. Overall, the PrISMa platform offers a comprehensive framework for evaluating and advancing carbon capture technologies, integrating materials science, process engineering, and environmental assessment to accelerate the development of sustainable solutions for reducing CO₂ emissions.