A lateralized brain network for visuospatial attention is described in this study. The research reveals that the right hemisphere has a larger parieto-frontal network than the left, and that the degree of anatomical lateralization correlates with asymmetry in visuospatial performance. The study used diffusion imaging tractography to examine the parieto-frontal connections in 20 right-handed subjects. The results showed a dorsal-to-ventral gradient of lateralization in the superior longitudinal fasciculus (SLF). The SLF I was symmetrically distributed between the hemispheres, while the SLF II showed a trend of right lateralization and the SLF III was right lateralized. The study also found that the lateralization of the SLF II was related to attentional bias for one visual hemi-field. Participants showed a left deviation in the line bisection test, which correlated with the volume of the SLF II on the right hemisphere. The study also found that larger SLF II volumes on the right hemisphere corresponded to faster detection times in the left hemi-field. These findings suggest that the anatomical asymmetry of the parieto-frontal connections predicts behavioral performance on visuospatial attention tasks. The study also suggests that the SLF II represents a direct communication between the dorsal and ventral networks during the orienting of attention. This communication may play the role of a modulator for the dorsal network, redirecting goal-directed attention mediated by the SLF I to events identified as salient by the SLF III. The study is the first to report the existence of a bilateral parieto-frontal network, previously described only in monkeys, whose hemispheric lateralization predicts the degree of specialization of the right hemisphere for visuospatial attention. The findings may help to interpret the neuroanatomical basis of current models of visuospatial attention based on functional imaging and studies of neglect patients.A lateralized brain network for visuospatial attention is described in this study. The research reveals that the right hemisphere has a larger parieto-frontal network than the left, and that the degree of anatomical lateralization correlates with asymmetry in visuospatial performance. The study used diffusion imaging tractography to examine the parieto-frontal connections in 20 right-handed subjects. The results showed a dorsal-to-ventral gradient of lateralization in the superior longitudinal fasciculus (SLF). The SLF I was symmetrically distributed between the hemispheres, while the SLF II showed a trend of right lateralization and the SLF III was right lateralized. The study also found that the lateralization of the SLF II was related to attentional bias for one visual hemi-field. Participants showed a left deviation in the line bisection test, which correlated with the volume of the SLF II on the right hemisphere. The study also found that larger SLF II volumes on the right hemisphere corresponded to faster detection times in the left hemi-field. These findings suggest that the anatomical asymmetry of the parieto-frontal connections predicts behavioral performance on visuospatial attention tasks. The study also suggests that the SLF II represents a direct communication between the dorsal and ventral networks during the orienting of attention. This communication may play the role of a modulator for the dorsal network, redirecting goal-directed attention mediated by the SLF I to events identified as salient by the SLF III. The study is the first to report the existence of a bilateral parieto-frontal network, previously described only in monkeys, whose hemispheric lateralization predicts the degree of specialization of the right hemisphere for visuospatial attention. The findings may help to interpret the neuroanatomical basis of current models of visuospatial attention based on functional imaging and studies of neglect patients.