This study conducted a genome-wide association study (GWAS) to identify new risk loci for Parkinson's disease (PD). The authors analyzed data from 6,476 PD cases and 302,042 controls, followed by a meta-analysis with a recent study of over 13,000 PD cases and 95,000 controls. They identified 17 novel risk loci (P < 5 × 10−8) in a joint analysis of 26,035 cases and 403,190 controls. Using a neurocentric strategy, they assigned candidate risk genes to these loci, finding that 29 of the 41 PD loci contained protein-altering or cis-expression quantitative trait locus (cis-eQTL) variants. These findings suggest a key role for autophagy and lysosomal biology in PD risk and potential new drug targets. The study involved a large-scale meta-analysis, providing valuable insights into the genetic basis of PD and potential therapeutic avenues.This study conducted a genome-wide association study (GWAS) to identify new risk loci for Parkinson's disease (PD). The authors analyzed data from 6,476 PD cases and 302,042 controls, followed by a meta-analysis with a recent study of over 13,000 PD cases and 95,000 controls. They identified 17 novel risk loci (P < 5 × 10−8) in a joint analysis of 26,035 cases and 403,190 controls. Using a neurocentric strategy, they assigned candidate risk genes to these loci, finding that 29 of the 41 PD loci contained protein-altering or cis-expression quantitative trait locus (cis-eQTL) variants. These findings suggest a key role for autophagy and lysosomal biology in PD risk and potential new drug targets. The study involved a large-scale meta-analysis, providing valuable insights into the genetic basis of PD and potential therapeutic avenues.