This paper proposes a modern, evidence-guided framework for teaching and practicing manual therapy (MT) that avoids the outdated principles of traditional manual therapy (TMT). The framework is based on three fundamental humanistic dimensions: safety, comfort, and efficiency, with positive communication, a collaborative context, and person-centered care as contextualizing elements. The authors review contemporary literature and engage a diverse group of stakeholders to develop this consensus-based framework. They argue that MT should include both passive and active, person-empowering interventions and be delivered in a well-developed therapeutic alliance. The paper emphasizes the importance of patient-centered assessments, communication, and a holistic approach to care, aligning with current evidence and contemporary theory. The framework is designed to be transdisciplinary and applicable across all MT professions, promoting an empowering, biopsychosocial, and evidence-informed approach to musculoskeletal care.This paper proposes a modern, evidence-guided framework for teaching and practicing manual therapy (MT) that avoids the outdated principles of traditional manual therapy (TMT). The framework is based on three fundamental humanistic dimensions: safety, comfort, and efficiency, with positive communication, a collaborative context, and person-centered care as contextualizing elements. The authors review contemporary literature and engage a diverse group of stakeholders to develop this consensus-based framework. They argue that MT should include both passive and active, person-empowering interventions and be delivered in a well-developed therapeutic alliance. The paper emphasizes the importance of patient-centered assessments, communication, and a holistic approach to care, aligning with current evidence and contemporary theory. The framework is designed to be transdisciplinary and applicable across all MT professions, promoting an empowering, biopsychosocial, and evidence-informed approach to musculoskeletal care.