The European Bioinformatics Institute (EMBL-EBI) has introduced a new bioinformatics analysis tools framework called JDispatcher, designed to enhance the accessibility and quality of its sequence analysis services. This framework aims to provide a uniform and consistent interface for both novice and expert users, offering novel methods for obtaining annotations and visualizing sequence analysis results. JDispatcher supports sequence similarity searches and multiple sequence alignments through web interfaces and Web Services interfaces (SOAP and REST). Key features include input validation, enhanced visualization tools, and integration of domain and functional predictions. The framework is available at http://www.ebi.ac.uk/Tools/ss for sequence similarity searches and at http://www.ebi.ac.uk/Tools/msa for multiple sequence alignments. It supports various programming languages and can be integrated into existing workflows and pipelines, making it a valuable resource for academic and commercial laboratories.The European Bioinformatics Institute (EMBL-EBI) has introduced a new bioinformatics analysis tools framework called JDispatcher, designed to enhance the accessibility and quality of its sequence analysis services. This framework aims to provide a uniform and consistent interface for both novice and expert users, offering novel methods for obtaining annotations and visualizing sequence analysis results. JDispatcher supports sequence similarity searches and multiple sequence alignments through web interfaces and Web Services interfaces (SOAP and REST). Key features include input validation, enhanced visualization tools, and integration of domain and functional predictions. The framework is available at http://www.ebi.ac.uk/Tools/ss for sequence similarity searches and at http://www.ebi.ac.uk/Tools/msa for multiple sequence alignments. It supports various programming languages and can be integrated into existing workflows and pipelines, making it a valuable resource for academic and commercial laboratories.