A new genomic blueprint of the human gut microbiota

A new genomic blueprint of the human gut microbiota

25 APRIL 2019 | Alexandre Almeida, Alex L. Mitchell, Miguel Boland, Samuel C. Forster, Gregory B. Gloor, Aleksandra Tarkowska, Trevor D. Lawley, Robert D. Finn
This study identifies 1,952 uncultured bacterial species by reconstructing 92,143 metagenome-assembled genomes from 11,850 human gut microbiomes. These uncultured genomes significantly expand the known species repertoire of the human gut microbiota, increasing phylogenetic diversity by 281%. The newly identified species are less prevalent in well-studied populations but improve classification of understudied African and South American samples by over 200%. These species encode hundreds of novel biosynthetic gene clusters and possess unique functional capacities, suggesting they play important roles in the gut environment. The study highlights the need for comprehensive reference databases and emphasizes the importance of sampling underrepresented regions to fully understand the diversity of the human gut microbiota.This study identifies 1,952 uncultured bacterial species by reconstructing 92,143 metagenome-assembled genomes from 11,850 human gut microbiomes. These uncultured genomes significantly expand the known species repertoire of the human gut microbiota, increasing phylogenetic diversity by 281%. The newly identified species are less prevalent in well-studied populations but improve classification of understudied African and South American samples by over 200%. These species encode hundreds of novel biosynthetic gene clusters and possess unique functional capacities, suggesting they play important roles in the gut environment. The study highlights the need for comprehensive reference databases and emphasizes the importance of sampling underrepresented regions to fully understand the diversity of the human gut microbiota.
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Understanding A new genomic blueprint of the human gut microbiota