The article introduces a novel parameter, the Cardio-Ankle Vascular Index (CAVI), which measures the stiffness of the aorta, femoral artery, and tibial artery without being influenced by blood pressure. The formula for CAVI is derived from Bramwell-Hill's equation and the stiffness parameter, and it includes factors such as pulse wave velocity (PWV), blood density, and blood pressures. The study evaluates the reproducibility and dependence on blood pressure of CAVI using VaSera equipment. In hemodialysis patients, CAVI showed weak correlation with systolic and diastolic blood pressures compared to brachial-ankle PWV, which had a strong correlation. CAVI values were significantly higher in patients with various arteriosclerotic diseases, including those with percutaneous transluminal coronary angioplasty, ischemic changes in electrocardiograms, and diabetes mellitus. These findings suggest that CAVI can quantitatively reflect arteriosclerosis in these patients. The article concludes that CAVI is a useful tool for assessing vascular stiffness and could be valuable in clinical practice, but further clinical data is needed to validate its utility.The article introduces a novel parameter, the Cardio-Ankle Vascular Index (CAVI), which measures the stiffness of the aorta, femoral artery, and tibial artery without being influenced by blood pressure. The formula for CAVI is derived from Bramwell-Hill's equation and the stiffness parameter, and it includes factors such as pulse wave velocity (PWV), blood density, and blood pressures. The study evaluates the reproducibility and dependence on blood pressure of CAVI using VaSera equipment. In hemodialysis patients, CAVI showed weak correlation with systolic and diastolic blood pressures compared to brachial-ankle PWV, which had a strong correlation. CAVI values were significantly higher in patients with various arteriosclerotic diseases, including those with percutaneous transluminal coronary angioplasty, ischemic changes in electrocardiograms, and diabetes mellitus. These findings suggest that CAVI can quantitatively reflect arteriosclerosis in these patients. The article concludes that CAVI is a useful tool for assessing vascular stiffness and could be valuable in clinical practice, but further clinical data is needed to validate its utility.