A novel coronavirus outbreak of global health concern

A novel coronavirus outbreak of global health concern

February 15, 2020 | Chen Wang, Peter W Horby, Frederick G Hayden, George F Gao
Elsevier established a free COVID-19 resource centre in January 2020, offering information in English and Mandarin. The centre grants permission for free access to its research in PubMed Central and other repositories. The 2019-nCoV outbreak began in Wuhan, China, with cases spreading globally. Early cases were linked to a seafood market, but subsequent cases suggested human-to-human transmission. The virus is a novel coronavirus, with symptoms including fever, dry cough, and malaise. Clinical features of the first 41 patients showed severe cases requiring ICU admission, with a case fatality rate of around 14.6%. However, this may be an overestimation due to limited data. The virus has a high mutation rate, and its origin, transmission, and pathogenesis remain unclear. The outbreak has raised concerns due to its potential for widespread transmission, especially during the Chinese Lunar New Year. Public health measures, including travel restrictions and surveillance, have been implemented. The availability of the virus's genetic sequence and initial data is crucial for understanding the threat. No specific antivirals or vaccines exist, but research is ongoing. The outbreak has prompted global collaboration to share data and provide real-time guidance. Clinicians are advised against using corticosteroids unless indicated. The situation remains dynamic, requiring continued monitoring and research.Elsevier established a free COVID-19 resource centre in January 2020, offering information in English and Mandarin. The centre grants permission for free access to its research in PubMed Central and other repositories. The 2019-nCoV outbreak began in Wuhan, China, with cases spreading globally. Early cases were linked to a seafood market, but subsequent cases suggested human-to-human transmission. The virus is a novel coronavirus, with symptoms including fever, dry cough, and malaise. Clinical features of the first 41 patients showed severe cases requiring ICU admission, with a case fatality rate of around 14.6%. However, this may be an overestimation due to limited data. The virus has a high mutation rate, and its origin, transmission, and pathogenesis remain unclear. The outbreak has raised concerns due to its potential for widespread transmission, especially during the Chinese Lunar New Year. Public health measures, including travel restrictions and surveillance, have been implemented. The availability of the virus's genetic sequence and initial data is crucial for understanding the threat. No specific antivirals or vaccines exist, but research is ongoing. The outbreak has prompted global collaboration to share data and provide real-time guidance. Clinicians are advised against using corticosteroids unless indicated. The situation remains dynamic, requiring continued monitoring and research.
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[slides and audio] A novel coronavirus outbreak of global health concern