A precision functional atlas of personalized network topography and probabilities

A precision functional atlas of personalized network topography and probabilities

May 2024 | Robert J. M. Hermosillo, Lucille A. Moore, Eric Feczko, Oscar Miranda-Dominguez, Adam Pines, Ally Dworetsky, Gregory Conan, Michael A. Mooney, Anita Randolph, Alice Graham, Babatunde Adeyemo, Eric Earl, Anders Perrone, Cristian Morales Carrasco, Johnny Uriarte-Lopez, Kathy Snider, Olivia Doyle, Michaela Cordova, Sanju Koirala, Gracie J. Grimsrud, Nora Byington, Steven M. Nelson, Caterina Gratton, Steven Petersen, Sarah W. Feldstein Ewing, Bonnie J. Nagel, Nico U. F. Dosenbach, Theodore D. Satterthwaite & Damien A. Fair
The MIDB Precision Brain Atlas is an open-source resource that provides individual-specific network maps and probabilistic maps for functional brain networks. It includes data from over 9,900 individuals across various age groups and studies, including the Adolescent Brain Cognitive Development (ABCD) study and the Developmental Human Connectome Project. The atlas uses precision functional mapping techniques to generate probabilistic network maps, which are more reliable than group-averaged parcellations for capturing individual variability in brain network topography. The atlas also includes integration zones that reflect the overlap of networks across individuals. The resource allows users to explore and contribute to the understanding of human brain function through an online interface. The atlas includes methods such as Infomap (IM), template matching (TM), non-negative matrix factorization (NMF), and an original overlapping network method (Overlapping MultiNetwork Imaging, OMNI) to generate individual-specific network maps. The atlas demonstrates high intraparticipant reliability and shows that probabilistic maps can improve the accuracy of brain-wide association studies (BWAS) by accounting for individual variability. The resource also provides a potential use case for probabilistic maps in targeted neuromodulation, such as transcranial magnetic stimulation (TMS), by allowing precise targeting of brain networks based on individual-specific functional connectivity. The atlas is expandable and encourages contributions from the scientific community to enhance the understanding of human brain function.The MIDB Precision Brain Atlas is an open-source resource that provides individual-specific network maps and probabilistic maps for functional brain networks. It includes data from over 9,900 individuals across various age groups and studies, including the Adolescent Brain Cognitive Development (ABCD) study and the Developmental Human Connectome Project. The atlas uses precision functional mapping techniques to generate probabilistic network maps, which are more reliable than group-averaged parcellations for capturing individual variability in brain network topography. The atlas also includes integration zones that reflect the overlap of networks across individuals. The resource allows users to explore and contribute to the understanding of human brain function through an online interface. The atlas includes methods such as Infomap (IM), template matching (TM), non-negative matrix factorization (NMF), and an original overlapping network method (Overlapping MultiNetwork Imaging, OMNI) to generate individual-specific network maps. The atlas demonstrates high intraparticipant reliability and shows that probabilistic maps can improve the accuracy of brain-wide association studies (BWAS) by accounting for individual variability. The resource also provides a potential use case for probabilistic maps in targeted neuromodulation, such as transcranial magnetic stimulation (TMS), by allowing precise targeting of brain networks based on individual-specific functional connectivity. The atlas is expandable and encourages contributions from the scientific community to enhance the understanding of human brain function.
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