A randomized trial compared normothermic machine perfusion (NMP) with conventional static cold storage (SCS) in liver transplantation. The study involved 220 liver transplants and found that NMP reduced graft injury by 50%, as measured by hepatocellular enzyme release, despite a 50% lower organ discard rate and a 54% longer preservation time. There were no significant differences in bile duct complications, graft survival, or patient survival. NMP improved organ utilization and preservation times, which could help address the shortage of donor organs. The study showed that NMP reduced peak serum aspartate transaminase (AST) levels by 49.4% and early allograft dysfunction by 74%. NMP also reduced the risk of biliary strictures and improved post-reperfusion hemodynamics. However, there were no significant differences in graft or patient survival. The study suggests that NMP could improve liver transplant outcomes and reduce waiting list mortality. The results indicate that NMP is a promising technique for liver preservation, but further research is needed to confirm its long-term benefits. The study was conducted by the Consortium for Organ Preservation in Europe and was funded by the European Commission. The trial was registered with the ISRCTN database and followed the CONSORT statement. The study found that NMP is safe and feasible, with over 120 livers transplanted in seven centers across four European countries. The results suggest that NMP could improve organ utilization and reduce waiting list mortality. The study highlights the potential of NMP to improve liver transplantation outcomes and reduce waiting list mortality. The study was conducted by the Consortium for Organ Preservation in Europe and was funded by the European Commission. The trial was registered with the ISRCTN database and followed the CONSORT statement. The study found that NMP is safe and feasible, with over 120 livers transplanted in seven centers across four European countries. The results suggest that NMP could improve organ utilization and reduce waiting list mortality. The study highlights the potential of NMP to improve liver transplantation outcomes and reduce waiting list mortality.A randomized trial compared normothermic machine perfusion (NMP) with conventional static cold storage (SCS) in liver transplantation. The study involved 220 liver transplants and found that NMP reduced graft injury by 50%, as measured by hepatocellular enzyme release, despite a 50% lower organ discard rate and a 54% longer preservation time. There were no significant differences in bile duct complications, graft survival, or patient survival. NMP improved organ utilization and preservation times, which could help address the shortage of donor organs. The study showed that NMP reduced peak serum aspartate transaminase (AST) levels by 49.4% and early allograft dysfunction by 74%. NMP also reduced the risk of biliary strictures and improved post-reperfusion hemodynamics. However, there were no significant differences in graft or patient survival. The study suggests that NMP could improve liver transplant outcomes and reduce waiting list mortality. The results indicate that NMP is a promising technique for liver preservation, but further research is needed to confirm its long-term benefits. The study was conducted by the Consortium for Organ Preservation in Europe and was funded by the European Commission. The trial was registered with the ISRCTN database and followed the CONSORT statement. The study found that NMP is safe and feasible, with over 120 livers transplanted in seven centers across four European countries. The results suggest that NMP could improve organ utilization and reduce waiting list mortality. The study highlights the potential of NMP to improve liver transplantation outcomes and reduce waiting list mortality. The study was conducted by the Consortium for Organ Preservation in Europe and was funded by the European Commission. The trial was registered with the ISRCTN database and followed the CONSORT statement. The study found that NMP is safe and feasible, with over 120 livers transplanted in seven centers across four European countries. The results suggest that NMP could improve organ utilization and reduce waiting list mortality. The study highlights the potential of NMP to improve liver transplantation outcomes and reduce waiting list mortality.