This review provides an overview of MRI findings in schizophrenia, spanning from 1988 to August 2000. The study of schizophrenia's neuropathology has a long history, with early researchers like Kraepelin and Bleuler suggesting an organic brain disorder. However, the neuropathology of schizophrenia remained unknown until the 1970s, when computer-assisted tomography (CT) and later magnetic resonance imaging (MRI) techniques emerged. MRI studies have since confirmed brain abnormalities in schizophrenia, particularly in ventricular enlargement (80% of studies), medial temporal lobe structures (74% of studies), and neocortical temporal lobe regions (100% of studies). Other abnormalities include frontal and parietal lobe volume reductions, subcortical abnormalities, and cerebellar abnormalities. The timing of these abnormalities is not fully understood, but some may be neurodevelopmental in origin or influenced by environmental factors. Future research should focus on homogeneous patient groups, at-risk populations, and advanced imaging techniques to better understand the neuropathology of schizophrenia.This review provides an overview of MRI findings in schizophrenia, spanning from 1988 to August 2000. The study of schizophrenia's neuropathology has a long history, with early researchers like Kraepelin and Bleuler suggesting an organic brain disorder. However, the neuropathology of schizophrenia remained unknown until the 1970s, when computer-assisted tomography (CT) and later magnetic resonance imaging (MRI) techniques emerged. MRI studies have since confirmed brain abnormalities in schizophrenia, particularly in ventricular enlargement (80% of studies), medial temporal lobe structures (74% of studies), and neocortical temporal lobe regions (100% of studies). Other abnormalities include frontal and parietal lobe volume reductions, subcortical abnormalities, and cerebellar abnormalities. The timing of these abnormalities is not fully understood, but some may be neurodevelopmental in origin or influenced by environmental factors. Future research should focus on homogeneous patient groups, at-risk populations, and advanced imaging techniques to better understand the neuropathology of schizophrenia.