Optical coherence tomography angiography (OCTA) is a non-invasive imaging technique that generates volumetric angiographic images in seconds. It has potential applications in retinal vascular disease but lacks level 1 clinical evidence. OCTA compares decorrelation signals between sequential OCT scans to create blood flow maps. It is faster and more detailed than traditional angiography methods like fluorescein angiography (FA) and indocyanine green angiography (ICGA), but has limitations such as a small field of view, inability to show leakage, and susceptibility to artifacts from movement or blinking. OCTA can detect choroidal blood flow changes and choroidal neovascularization (CNV), particularly in age-related macular degeneration (AMD). It provides detailed retinal vasculature images, aiding in the detection of subtle microvascular abnormalities and the foveal avascular zone (FAZ) in diabetic eyes. OCTA also visualizes optic disc perfusion in glaucomatous eyes. While OCTA is non-invasive and provides structural and functional information, it may miss slow blood flow areas and is less effective in detecting leakage. Future studies are needed to confirm its clinical utility and potential as a non-invasive tool for retinal vasculature visualization. OCTA is promising for evaluating AMD, diabetic retinopathy, vascular occlusions, and glaucoma, with ongoing research aiming to improve its speed and resolution.Optical coherence tomography angiography (OCTA) is a non-invasive imaging technique that generates volumetric angiographic images in seconds. It has potential applications in retinal vascular disease but lacks level 1 clinical evidence. OCTA compares decorrelation signals between sequential OCT scans to create blood flow maps. It is faster and more detailed than traditional angiography methods like fluorescein angiography (FA) and indocyanine green angiography (ICGA), but has limitations such as a small field of view, inability to show leakage, and susceptibility to artifacts from movement or blinking. OCTA can detect choroidal blood flow changes and choroidal neovascularization (CNV), particularly in age-related macular degeneration (AMD). It provides detailed retinal vasculature images, aiding in the detection of subtle microvascular abnormalities and the foveal avascular zone (FAZ) in diabetic eyes. OCTA also visualizes optic disc perfusion in glaucomatous eyes. While OCTA is non-invasive and provides structural and functional information, it may miss slow blood flow areas and is less effective in detecting leakage. Future studies are needed to confirm its clinical utility and potential as a non-invasive tool for retinal vasculature visualization. OCTA is promising for evaluating AMD, diabetic retinopathy, vascular occlusions, and glaucoma, with ongoing research aiming to improve its speed and resolution.