Optical coherence tomography angiography (OCTA) is a non-invasive imaging technique that generates volumetric angiography images quickly, offering potential for diagnosing retinal vascular diseases. It provides detailed structural and blood flow information, allowing for the localization and delineation of pathology. However, OCTA has limitations, including a small field of view, inability to show leakage, and susceptibility to artifacts from patient movement. Studies suggest its potential in evaluating conditions like age-related macular degeneration (AMD), diabetic retinopathy, retinal vascular occlusions, and glaucoma. OCTA can detect changes in choroidal blood flow and identify choroidal neovascularization (CNV), particularly in AMD. It also aids in assessing the foveal avascular zone (FAZ) in diabetic eyes and detecting microvascular abnormalities. Compared to traditional angiographic methods like fluorescein angiography (FA) and indocyanine green angiography (ICGA), OCTA is non-invasive and does not require dye, but it lacks the ability to visualize leakage and has limited depth resolution. Further research is needed to establish its clinical utility and potential as a non-invasive alternative for retinal vasculature imaging.Optical coherence tomography angiography (OCTA) is a non-invasive imaging technique that generates volumetric angiography images quickly, offering potential for diagnosing retinal vascular diseases. It provides detailed structural and blood flow information, allowing for the localization and delineation of pathology. However, OCTA has limitations, including a small field of view, inability to show leakage, and susceptibility to artifacts from patient movement. Studies suggest its potential in evaluating conditions like age-related macular degeneration (AMD), diabetic retinopathy, retinal vascular occlusions, and glaucoma. OCTA can detect changes in choroidal blood flow and identify choroidal neovascularization (CNV), particularly in AMD. It also aids in assessing the foveal avascular zone (FAZ) in diabetic eyes and detecting microvascular abnormalities. Compared to traditional angiographic methods like fluorescein angiography (FA) and indocyanine green angiography (ICGA), OCTA is non-invasive and does not require dye, but it lacks the ability to visualize leakage and has limited depth resolution. Further research is needed to establish its clinical utility and potential as a non-invasive alternative for retinal vasculature imaging.