This review discusses antimicrobial strategies to prevent biofilm-associated infections on medical implants. Biofilms, formed by bacteria adhering to surfaces and enclosed in an extracellular matrix, are a major cause of implant failure and chronic infections. The review covers various types of implants, including dental, orthopedic, tracheal, breast, central venous catheter, cochlear, urinary, intraocular lens, and heart valve implants, as well as medical devices like hemodialyzers and pacemakers. It explores the mechanisms of biofilm formation on these implants and the pathogenesis of infections. The review critically evaluates various approaches to combat implant-associated infections, with a focus on non-antibiotic alternatives. Dental implants are particularly susceptible to biofilm formation, often dominated by Gram-negative bacteria such as Porphyromonas gingivalis and Streptococcus species. Quorum sensing inhibitors and phytochemicals have shown promise in preventing biofilm formation. Candida species, including C. albicans, can also form biofilms on dental implants, contributing to implant failure. Antimicrobial compounds like tea tree oil, eucalyptus oil, and shikonin have demonstrated efficacy in inhibiting biofilm formation. Orthopedic implants are at risk of biofilm-associated infections, often caused by Gram-positive bacteria such as S. aureus and S. epidermidis. Antimicrobial strategies include antibiotic coatings, nanoparticles, and bioactive glass. Silver nanoparticles and other antimicrobial coatings have shown potential in reducing biofilm formation on orthopedic implants. Cochlear implants are prone to biofilm formation, often involving S. aureus and P. aeruginosa. Antimicrobial strategies include phytochemicals, silver nanoparticles, and surface modifications. Biofilm formation on tracheal stents is also a concern, with silver nanoparticles and other antimicrobial agents showing promise in reducing biofilm formation. Central venous catheters (CVCs) are at risk of biofilm-associated infections, often caused by S. aureus and P. aeruginosa. Antimicrobial coatings, such as sulfadiazine-chlorhexidine and minocycline-rifampin, have been used to prevent biofilm formation. Antimicrobial irrigation and lock solutions are also effective in reducing biofilm formation on CVCs. Breast implants can develop biofilms leading to complications such as capsular contracture and BI-ALCL. Antimicrobial irrigation and coatings with antibiotics have been used to prevent biofilm formation. Hemodialyzers are at risk of biofilm formation, often involving P. aeruginosa and Burkholderia cepacia. Physical and chemical treatments, such as citric acid and heat disinfection, have been used to remove biofilms. Urinary catheters are prone to biofilm formation, often involving Gram-positive and Gram-negative bacteria. Antimicrobial coatings and irrigation have been used to prevent biofilmThis review discusses antimicrobial strategies to prevent biofilm-associated infections on medical implants. Biofilms, formed by bacteria adhering to surfaces and enclosed in an extracellular matrix, are a major cause of implant failure and chronic infections. The review covers various types of implants, including dental, orthopedic, tracheal, breast, central venous catheter, cochlear, urinary, intraocular lens, and heart valve implants, as well as medical devices like hemodialyzers and pacemakers. It explores the mechanisms of biofilm formation on these implants and the pathogenesis of infections. The review critically evaluates various approaches to combat implant-associated infections, with a focus on non-antibiotic alternatives. Dental implants are particularly susceptible to biofilm formation, often dominated by Gram-negative bacteria such as Porphyromonas gingivalis and Streptococcus species. Quorum sensing inhibitors and phytochemicals have shown promise in preventing biofilm formation. Candida species, including C. albicans, can also form biofilms on dental implants, contributing to implant failure. Antimicrobial compounds like tea tree oil, eucalyptus oil, and shikonin have demonstrated efficacy in inhibiting biofilm formation. Orthopedic implants are at risk of biofilm-associated infections, often caused by Gram-positive bacteria such as S. aureus and S. epidermidis. Antimicrobial strategies include antibiotic coatings, nanoparticles, and bioactive glass. Silver nanoparticles and other antimicrobial coatings have shown potential in reducing biofilm formation on orthopedic implants. Cochlear implants are prone to biofilm formation, often involving S. aureus and P. aeruginosa. Antimicrobial strategies include phytochemicals, silver nanoparticles, and surface modifications. Biofilm formation on tracheal stents is also a concern, with silver nanoparticles and other antimicrobial agents showing promise in reducing biofilm formation. Central venous catheters (CVCs) are at risk of biofilm-associated infections, often caused by S. aureus and P. aeruginosa. Antimicrobial coatings, such as sulfadiazine-chlorhexidine and minocycline-rifampin, have been used to prevent biofilm formation. Antimicrobial irrigation and lock solutions are also effective in reducing biofilm formation on CVCs. Breast implants can develop biofilms leading to complications such as capsular contracture and BI-ALCL. Antimicrobial irrigation and coatings with antibiotics have been used to prevent biofilm formation. Hemodialyzers are at risk of biofilm formation, often involving P. aeruginosa and Burkholderia cepacia. Physical and chemical treatments, such as citric acid and heat disinfection, have been used to remove biofilms. Urinary catheters are prone to biofilm formation, often involving Gram-positive and Gram-negative bacteria. Antimicrobial coatings and irrigation have been used to prevent biofilm