The study aims to determine the combination and doses of drugs and vitamins in a single daily pill to significantly reduce cardiovascular disease (CVD) with minimal adverse effects. The proposed formulation includes a statin (e.g., atorvastatin or simvastatin), three blood pressure-lowering drugs (thiazide, β-blocker, and angiotensin-converting enzyme inhibitor), folic acid, and aspirin. This combination, called the Polypill, is estimated to reduce ischemic heart disease (IHD) events by 88% and strokes by 80%. About one-third of people aged 55 and older would benefit, gaining an average of 11 years of life free from IHD events or strokes. The Polypill is expected to cause symptoms in 8-15% of users, depending on the specific formulation. The study concludes that the Polypill strategy could significantly prevent heart attacks and strokes if taken by everyone aged 55 and older and those with existing cardiovascular disease, with a low risk of adverse effects.The study aims to determine the combination and doses of drugs and vitamins in a single daily pill to significantly reduce cardiovascular disease (CVD) with minimal adverse effects. The proposed formulation includes a statin (e.g., atorvastatin or simvastatin), three blood pressure-lowering drugs (thiazide, β-blocker, and angiotensin-converting enzyme inhibitor), folic acid, and aspirin. This combination, called the Polypill, is estimated to reduce ischemic heart disease (IHD) events by 88% and strokes by 80%. About one-third of people aged 55 and older would benefit, gaining an average of 11 years of life free from IHD events or strokes. The Polypill is expected to cause symptoms in 8-15% of users, depending on the specific formulation. The study concludes that the Polypill strategy could significantly prevent heart attacks and strokes if taken by everyone aged 55 and older and those with existing cardiovascular disease, with a low risk of adverse effects.