The Gaza Strip faces a severe water quality and quantity crisis, with groundwater being the primary source for drinking, agricultural, and industrial use. Salinity in groundwater is increasing due to seawater intrusion, which is the main source of sodium chloride. Chloride concentration is used as an indicator of salinity, and three models—forecasting, linear regression, and multiple regression—are used to predict chloride levels by 2023. All models predict a rise in salinity across the Gaza Strip, with only a small area in the North Governorate maintaining chloride levels below 250 mg/L, representing 4.56% of the total area. Seawater intrusion is evident along the coastline, extending from the Mediterranean Sea to the eastern part of the Gaza Strip. The study uses GIS and interpolation methods to analyze chloride concentration trends and model future scenarios. The results show a significant increase in salinity, with the highest levels in urban areas. Multiple linear regression is the most accurate model, followed by forecasting and linear regression. The study highlights the urgent need for water management strategies to mitigate the impact of salinity on agriculture and public health. The research also discusses the potential of desalination plants to provide safe drinking water, with the EU investing in such projects to address the water crisis. Overall, the study underscores the critical importance of managing groundwater resources to ensure sustainable water supply in the Gaza Strip.The Gaza Strip faces a severe water quality and quantity crisis, with groundwater being the primary source for drinking, agricultural, and industrial use. Salinity in groundwater is increasing due to seawater intrusion, which is the main source of sodium chloride. Chloride concentration is used as an indicator of salinity, and three models—forecasting, linear regression, and multiple regression—are used to predict chloride levels by 2023. All models predict a rise in salinity across the Gaza Strip, with only a small area in the North Governorate maintaining chloride levels below 250 mg/L, representing 4.56% of the total area. Seawater intrusion is evident along the coastline, extending from the Mediterranean Sea to the eastern part of the Gaza Strip. The study uses GIS and interpolation methods to analyze chloride concentration trends and model future scenarios. The results show a significant increase in salinity, with the highest levels in urban areas. Multiple linear regression is the most accurate model, followed by forecasting and linear regression. The study highlights the urgent need for water management strategies to mitigate the impact of salinity on agriculture and public health. The research also discusses the potential of desalination plants to provide safe drinking water, with the EU investing in such projects to address the water crisis. Overall, the study underscores the critical importance of managing groundwater resources to ensure sustainable water supply in the Gaza Strip.