The Gaza Strip faces a severe water quality and quantity crisis, with groundwater being the primary source for drinking, agricultural, and industrial uses. Salinity in groundwater is increasing, primarily due to seawater intrusion. This study uses chloride ion-selective electrodes as an indicator of salinity to analyze and model groundwater salinity in the Gaza Strip up to 2023. Three models—Forecasting, Linear Regression, and Multiple Regression—are employed to predict chloride concentration changes. The results indicate that salinity will increase in all areas of the Gaza Strip by 2023, with only a small area in the North Governorate maintaining chloride concentrations below 250 mg/L, representing 4.56% of the total area. Seawater intrusion is evident along the coastline, extending from the Mediterranean Sea to the east of the Gaza Strip. The study also highlights the impact of urban expansion and population growth on water quality and quantity, emphasizing the need for effective management and alternative solutions such as desalination plants.The Gaza Strip faces a severe water quality and quantity crisis, with groundwater being the primary source for drinking, agricultural, and industrial uses. Salinity in groundwater is increasing, primarily due to seawater intrusion. This study uses chloride ion-selective electrodes as an indicator of salinity to analyze and model groundwater salinity in the Gaza Strip up to 2023. Three models—Forecasting, Linear Regression, and Multiple Regression—are employed to predict chloride concentration changes. The results indicate that salinity will increase in all areas of the Gaza Strip by 2023, with only a small area in the North Governorate maintaining chloride concentrations below 250 mg/L, representing 4.56% of the total area. Seawater intrusion is evident along the coastline, extending from the Mediterranean Sea to the east of the Gaza Strip. The study also highlights the impact of urban expansion and population growth on water quality and quantity, emphasizing the need for effective management and alternative solutions such as desalination plants.