The article outlines a vision for the future of genomics research, emphasizing the completion of the Human Genome Project (HGP) as a landmark achievement. It highlights the transformative impact of genomics on biology, health, and society, and outlines a blueprint for future research directions. Key themes include elucidating genome structure and function, translating genomic knowledge into health benefits, and addressing ethical, legal, and social implications. The authors propose grand challenges in areas such as identifying genetic components, understanding evolutionary variation, developing robust strategies for disease prediction, and improving health equity. They stress the importance of interdisciplinary collaboration, training, and policy development to maximize benefits and minimize harms. The vision aims to build on the foundation laid by the HGP, fostering a cohesive discipline of biomedical research and addressing societal challenges through genomics.The article outlines a vision for the future of genomics research, emphasizing the completion of the Human Genome Project (HGP) as a landmark achievement. It highlights the transformative impact of genomics on biology, health, and society, and outlines a blueprint for future research directions. Key themes include elucidating genome structure and function, translating genomic knowledge into health benefits, and addressing ethical, legal, and social implications. The authors propose grand challenges in areas such as identifying genetic components, understanding evolutionary variation, developing robust strategies for disease prediction, and improving health equity. They stress the importance of interdisciplinary collaboration, training, and policy development to maximize benefits and minimize harms. The vision aims to build on the foundation laid by the HGP, fostering a cohesive discipline of biomedical research and addressing societal challenges through genomics.