A wearable and highly sensitive pressure sensor based on ultrathin gold nanowires (AuNWs) is reported. The sensor is fabricated by sandwiching AuNWs-impregnated tissue paper between two thin polydimethylsiloxane (PDMS) sheets. The AuNWs, with a width of ~2 nm and an aspect ratio of >10,000, are mechanically flexible and robust, making them suitable for flexible electronics. The sensor operates at a battery voltage of 1.5 V with low energy consumption (<30 μW) and can detect pressures as low as 13 Pa with a fast response time (<17 ms), high sensitivity (>1.14 kPa⁻¹), and high stability (>50,000 loading-unloading cycles). It can detect pressing, bending, torsional forces, and acoustic vibrations. The sensor is used for real-time monitoring of blood pulses and detection of small vibration forces from music. The fabrication process is scalable, enabling large-area integration and spatial pressure mapping. The sensor's performance is comparable to other recent pressure sensing devices, offering advantages of low cost and simplicity in fabrication. The sensor is also used for detecting wrist pulses and acoustic vibrations, demonstrating its potential for wearable health monitoring and other applications. The sensor's high sensitivity and stability make it suitable for various flexible electronics applications. The fabrication method is general and can be extended to other nanomaterials such as carbon nanotubes and gold nanorods. The sensor's unique properties, including high mechanical flexibility and conductivity, enable its use in a wide range of applications. The sensor's performance is validated through various tests, including cycling tests, sensitivity tests, and durability tests. The sensor's ability to detect dynamic forces in a wide pressure range (13–50,000 Pa) and resolve various complex forces makes it a promising candidate for wearable electronics. The sensor's low power consumption and high sensitivity make it suitable for real-time health monitoring and other applications. The sensor's fabrication process is scalable and enables large-area integration and patterning. The sensor's performance is compared to other pressure sensing devices, demonstrating its potential for future wearable electronics. The sensor's ability to detect various types of mechanical forces and acoustic vibrations makes it a versatile device for a wide range of applications. The sensor's high sensitivity and stability make it suitable for real-time monitoring of blood pulses and other physiological signals. The sensor's fabrication method is simple and efficient, enabling large-scale production. The sensor's performance is validated through various tests, including cycling tests, sensitivity tests, and durability tests. The sensor's ability to detect dynamic forces in a wide pressure range (13–50,000 Pa) and resolve various complex forces makes it a promising candidate for wearable electronics. The sensor's low power consumption and high sensitivity make it suitable for real-time health monitoring and other applications. The sensor's fabrication process is scalable andA wearable and highly sensitive pressure sensor based on ultrathin gold nanowires (AuNWs) is reported. The sensor is fabricated by sandwiching AuNWs-impregnated tissue paper between two thin polydimethylsiloxane (PDMS) sheets. The AuNWs, with a width of ~2 nm and an aspect ratio of >10,000, are mechanically flexible and robust, making them suitable for flexible electronics. The sensor operates at a battery voltage of 1.5 V with low energy consumption (<30 μW) and can detect pressures as low as 13 Pa with a fast response time (<17 ms), high sensitivity (>1.14 kPa⁻¹), and high stability (>50,000 loading-unloading cycles). It can detect pressing, bending, torsional forces, and acoustic vibrations. The sensor is used for real-time monitoring of blood pulses and detection of small vibration forces from music. The fabrication process is scalable, enabling large-area integration and spatial pressure mapping. The sensor's performance is comparable to other recent pressure sensing devices, offering advantages of low cost and simplicity in fabrication. The sensor is also used for detecting wrist pulses and acoustic vibrations, demonstrating its potential for wearable health monitoring and other applications. The sensor's high sensitivity and stability make it suitable for various flexible electronics applications. The fabrication method is general and can be extended to other nanomaterials such as carbon nanotubes and gold nanorods. The sensor's unique properties, including high mechanical flexibility and conductivity, enable its use in a wide range of applications. The sensor's performance is validated through various tests, including cycling tests, sensitivity tests, and durability tests. The sensor's ability to detect dynamic forces in a wide pressure range (13–50,000 Pa) and resolve various complex forces makes it a promising candidate for wearable electronics. The sensor's low power consumption and high sensitivity make it suitable for real-time health monitoring and other applications. The sensor's fabrication process is scalable and enables large-area integration and patterning. The sensor's performance is compared to other pressure sensing devices, demonstrating its potential for future wearable electronics. The sensor's ability to detect various types of mechanical forces and acoustic vibrations makes it a versatile device for a wide range of applications. The sensor's high sensitivity and stability make it suitable for real-time monitoring of blood pulses and other physiological signals. The sensor's fabrication method is simple and efficient, enabling large-scale production. The sensor's performance is validated through various tests, including cycling tests, sensitivity tests, and durability tests. The sensor's ability to detect dynamic forces in a wide pressure range (13–50,000 Pa) and resolve various complex forces makes it a promising candidate for wearable electronics. The sensor's low power consumption and high sensitivity make it suitable for real-time health monitoring and other applications. The sensor's fabrication process is scalable and