This study presents a wireless, battery-free eye modulation patch designed to correct high myopia and prevent relapse. The patch integrates piezoelectric transducers, an electrochemical micro-actuator, a drug microneedle array, μ-LEDs, a flexible circuit, and biocompatible encapsulation. It can be wirelessly powered and controlled using external ultrasound. The electrochemical micro-actuator shortens the axial length by driving the posterior sclera inward, ensuring accurate scene imaging on the retina. The drug microneedle array delivers riboflavin to the posterior sclera, while μ-LEDs induce collagen cross-linking to reinforce scleral strength. In vivo experiments on rabbits showed that the patch reduced the axial length by ~1217 μm and increased scleral strength by 387%. The system operates effectively within the body without batteries, offering a promising approach for clinically treating high myopia. The study highlights the potential of this multifunctional therapeutic device to address the challenges of progressive and pathological myopia by targeting axial elongation and scleral relaxation.This study presents a wireless, battery-free eye modulation patch designed to correct high myopia and prevent relapse. The patch integrates piezoelectric transducers, an electrochemical micro-actuator, a drug microneedle array, μ-LEDs, a flexible circuit, and biocompatible encapsulation. It can be wirelessly powered and controlled using external ultrasound. The electrochemical micro-actuator shortens the axial length by driving the posterior sclera inward, ensuring accurate scene imaging on the retina. The drug microneedle array delivers riboflavin to the posterior sclera, while μ-LEDs induce collagen cross-linking to reinforce scleral strength. In vivo experiments on rabbits showed that the patch reduced the axial length by ~1217 μm and increased scleral strength by 387%. The system operates effectively within the body without batteries, offering a promising approach for clinically treating high myopia. The study highlights the potential of this multifunctional therapeutic device to address the challenges of progressive and pathological myopia by targeting axial elongation and scleral relaxation.