The study by Shaman and Kohn explores the impact of absolute humidity (AH) on the transmission and survival of influenza A (IVT and IVS) in temperate regions. They reanalyze previous data to compare the effects of AH and relative humidity (RH) on IVT and IVS. The results show that AH significantly constrains both IVT and IVS, explaining 50% and 90% of variability, respectively, compared to only 12% and 36% explained by RH. The seasonal cycle of AH in both indoor and outdoor environments aligns with the wintertime increase in IVS and IVT, suggesting that changes in AH may explain the seasonality of influenza. The authors propose that humidifying indoor air could potentially reduce influenza transmission, particularly in high-risk settings. However, the precise mechanisms by which AH affects IVS remain unclear, and further laboratory and modeling studies are needed to validate these findings and explore the effects of AH on other modes of IVT.The study by Shaman and Kohn explores the impact of absolute humidity (AH) on the transmission and survival of influenza A (IVT and IVS) in temperate regions. They reanalyze previous data to compare the effects of AH and relative humidity (RH) on IVT and IVS. The results show that AH significantly constrains both IVT and IVS, explaining 50% and 90% of variability, respectively, compared to only 12% and 36% explained by RH. The seasonal cycle of AH in both indoor and outdoor environments aligns with the wintertime increase in IVS and IVT, suggesting that changes in AH may explain the seasonality of influenza. The authors propose that humidifying indoor air could potentially reduce influenza transmission, particularly in high-risk settings. However, the precise mechanisms by which AH affects IVS remain unclear, and further laboratory and modeling studies are needed to validate these findings and explore the effects of AH on other modes of IVT.