The article investigates the role of Lysosome-associated membrane protein-2 (LAMP-2) in autophagy and its implications for cardiomyopathy and myopathy. LAMP-2-deficient mice exhibit increased mortality between 20 and 40 days of age, with surviving mice showing extensive accumulation of autophagic vacuoles in various tissues, including liver, pancreas, spleen, kidney, and skeletal and heart muscle. Ultrastructurally, these vacuoles are filled with cytosol, endoplasmic reticulum, glycogen, and mitochondria. In hepatocytes, the degradation of long-lived proteins is severely impaired, and cardiac myocytes show ultrastructural abnormalities and reduced heart contractility. These findings suggest that LAMP-2 is critical for autophagy. The authors also note that human LAMP-2 deficiency, causing Danon's disease, is associated with the accumulation of autophagic material in striated myocytes. The study highlights the importance of LAMP-2 in the maturation and function of autophagosomes, providing insights into the pathogenesis of LAMP-2-related diseases.The article investigates the role of Lysosome-associated membrane protein-2 (LAMP-2) in autophagy and its implications for cardiomyopathy and myopathy. LAMP-2-deficient mice exhibit increased mortality between 20 and 40 days of age, with surviving mice showing extensive accumulation of autophagic vacuoles in various tissues, including liver, pancreas, spleen, kidney, and skeletal and heart muscle. Ultrastructurally, these vacuoles are filled with cytosol, endoplasmic reticulum, glycogen, and mitochondria. In hepatocytes, the degradation of long-lived proteins is severely impaired, and cardiac myocytes show ultrastructural abnormalities and reduced heart contractility. These findings suggest that LAMP-2 is critical for autophagy. The authors also note that human LAMP-2 deficiency, causing Danon's disease, is associated with the accumulation of autophagic material in striated myocytes. The study highlights the importance of LAMP-2 in the maturation and function of autophagosomes, providing insights into the pathogenesis of LAMP-2-related diseases.