In 2005, a study evaluated the accuracy of 64-slice computed tomography (CT) coronary angiography in detecting haemodynamically significant coronary artery stenoses. The study involved 67 patients with suspected coronary artery disease (CAD) who underwent both invasive coronary angiography (ICA) and 64-slice CT coronary angiography. The CT scan correctly identified all patients without significant stenoses, with an overall sensitivity of 94%, specificity of 97%, positive predictive value of 87%, and negative predictive value of 99%. The 64-slice CT scanner provided high-resolution images with 0.4 mm isotropic voxels and a rotation time of 0.37 seconds, improving spatial and temporal resolution compared to previous CT technologies. The study found that no coronary segments had to be excluded from analysis, and the CT scan accurately detected 165 out of 176 significant stenoses identified by ICA. The high negative predictive value of 99% suggests that CT coronary angiography can reliably exclude CAD in patients with equivocal clinical presentations. The study also noted that motion artifacts and severe coronary calcifications were the main limitations for reliable assessment of all coronary segments. Despite these challenges, the 64-slice CT scan demonstrated excellent inter-observer agreement and a high diagnostic accuracy. The study concluded that 64-slice CT allows a non-invasive assessment of haemodynamically significant CAD with high diagnostic accuracy, although further studies are needed to determine the threshold for reliable assessment of coronary artery stenosis. The study was supported by the National Center of Competence and Research, Computer Aided and Image Guided Medical Interventions (NCCR CO-ME) of the Swiss National Science Foundation.In 2005, a study evaluated the accuracy of 64-slice computed tomography (CT) coronary angiography in detecting haemodynamically significant coronary artery stenoses. The study involved 67 patients with suspected coronary artery disease (CAD) who underwent both invasive coronary angiography (ICA) and 64-slice CT coronary angiography. The CT scan correctly identified all patients without significant stenoses, with an overall sensitivity of 94%, specificity of 97%, positive predictive value of 87%, and negative predictive value of 99%. The 64-slice CT scanner provided high-resolution images with 0.4 mm isotropic voxels and a rotation time of 0.37 seconds, improving spatial and temporal resolution compared to previous CT technologies. The study found that no coronary segments had to be excluded from analysis, and the CT scan accurately detected 165 out of 176 significant stenoses identified by ICA. The high negative predictive value of 99% suggests that CT coronary angiography can reliably exclude CAD in patients with equivocal clinical presentations. The study also noted that motion artifacts and severe coronary calcifications were the main limitations for reliable assessment of all coronary segments. Despite these challenges, the 64-slice CT scan demonstrated excellent inter-observer agreement and a high diagnostic accuracy. The study concluded that 64-slice CT allows a non-invasive assessment of haemodynamically significant CAD with high diagnostic accuracy, although further studies are needed to determine the threshold for reliable assessment of coronary artery stenosis. The study was supported by the National Center of Competence and Research, Computer Aided and Image Guided Medical Interventions (NCCR CO-ME) of the Swiss National Science Foundation.