Perovskite solar cells (PSCs) have achieved a certified power conversion efficiency (PCE) of 26.1% in just over a decade, making them a promising candidate for industrialization. However, challenges such as long-term stability, scalability, and sustainability remain significant barriers. This review outlines the key challenges in PSC industrialization, including technological limitations, multi-scenario applications, and sustainable development. The article discusses strategies to address these challenges, focusing on improving crystal quality, defect passivation, and charge extraction. To enhance crystal quality, precise control of solvent evaporation rates and the use of additives like DMSO and dimethylammonium are crucial. These methods help form high-quality perovskite films with minimal grain boundaries and improved uniformity. Defect passivation is another critical area, with Lewis acid and base additives playing a key role in reducing non-radiative recombination and enhancing device performance. For example, RbI and TFPN have been shown to effectively passivate defects, leading to higher PCE and improved stability. Charge extraction is improved through optimized energy level alignment at the interface between the perovskite and charge transport layers (ETL/HTL). The use of self-assembled monolayers and tailored functional groups enhances the work function and band alignment, leading to better hole and electron extraction. Additionally, the development of tandem solar cells, such as perovskite/Si and perovskite/organic, has shown promising results, with PCEs exceeding 33.7% for perovskite/Si tandem cells. Despite these advancements, challenges such as thermal stability, phase segregation, and environmental factors like humidity and oxygen remain. Strategies to enhance thermal stability include adjusting the tolerance factor and using all-inorganic perovskites like CsPbI3, which exhibit superior resistance to thermal stress. The integration of systematic theoretical simulations and experimental verification is essential for achieving effective passivation and improving overall device performance. In conclusion, the industrialization of PSCs requires addressing technological limitations, ensuring long-term stability, and promoting sustainable development. Through continued research and innovation, PSCs have the potential to become a viable and environmentally responsible energy solution.Perovskite solar cells (PSCs) have achieved a certified power conversion efficiency (PCE) of 26.1% in just over a decade, making them a promising candidate for industrialization. However, challenges such as long-term stability, scalability, and sustainability remain significant barriers. This review outlines the key challenges in PSC industrialization, including technological limitations, multi-scenario applications, and sustainable development. The article discusses strategies to address these challenges, focusing on improving crystal quality, defect passivation, and charge extraction. To enhance crystal quality, precise control of solvent evaporation rates and the use of additives like DMSO and dimethylammonium are crucial. These methods help form high-quality perovskite films with minimal grain boundaries and improved uniformity. Defect passivation is another critical area, with Lewis acid and base additives playing a key role in reducing non-radiative recombination and enhancing device performance. For example, RbI and TFPN have been shown to effectively passivate defects, leading to higher PCE and improved stability. Charge extraction is improved through optimized energy level alignment at the interface between the perovskite and charge transport layers (ETL/HTL). The use of self-assembled monolayers and tailored functional groups enhances the work function and band alignment, leading to better hole and electron extraction. Additionally, the development of tandem solar cells, such as perovskite/Si and perovskite/organic, has shown promising results, with PCEs exceeding 33.7% for perovskite/Si tandem cells. Despite these advancements, challenges such as thermal stability, phase segregation, and environmental factors like humidity and oxygen remain. Strategies to enhance thermal stability include adjusting the tolerance factor and using all-inorganic perovskites like CsPbI3, which exhibit superior resistance to thermal stress. The integration of systematic theoretical simulations and experimental verification is essential for achieving effective passivation and improving overall device performance. In conclusion, the industrialization of PSCs requires addressing technological limitations, ensuring long-term stability, and promoting sustainable development. Through continued research and innovation, PSCs have the potential to become a viable and environmentally responsible energy solution.