Since January 2020, Elsevier has established a COVID-19 resource center on its public news and information website, Elsevier Connect, providing free information in English and Mandarin about the novel coronavirus. The company has granted permission to make all its COVID-19-related research available in PubMed Central and other public repositories, allowing unrestricted reuse and analysis with acknowledgment of the original source. The article "Adaptive Immunity to SARS-CoV-2 and COVID-19" by Alessandro Sette and Shane Crotty reviews the role of adaptive immunity in controlling SARS-CoV-2 infections. The adaptive immune system, consisting of B cells, CD4+ T cells, and CD8+ T cells, plays a crucial role in both non-hospitalized and hospitalized cases of COVID-19. CD4+ T cells, CD8+ T cells, and neutralizing antibodies all contribute to controlling SARS-CoV-2 infection. The specific functions and kinetics of these immune responses, as well as their interaction with innate immunity, are discussed, along with implications for COVID-19 vaccines and immune memory against reinfection. The review highlights the importance of early adaptive immune responses in controlling the infection and the potential role of T cells in preventing severe COVID-19.Since January 2020, Elsevier has established a COVID-19 resource center on its public news and information website, Elsevier Connect, providing free information in English and Mandarin about the novel coronavirus. The company has granted permission to make all its COVID-19-related research available in PubMed Central and other public repositories, allowing unrestricted reuse and analysis with acknowledgment of the original source. The article "Adaptive Immunity to SARS-CoV-2 and COVID-19" by Alessandro Sette and Shane Crotty reviews the role of adaptive immunity in controlling SARS-CoV-2 infections. The adaptive immune system, consisting of B cells, CD4+ T cells, and CD8+ T cells, plays a crucial role in both non-hospitalized and hospitalized cases of COVID-19. CD4+ T cells, CD8+ T cells, and neutralizing antibodies all contribute to controlling SARS-CoV-2 infection. The specific functions and kinetics of these immune responses, as well as their interaction with innate immunity, are discussed, along with implications for COVID-19 vaccines and immune memory against reinfection. The review highlights the importance of early adaptive immune responses in controlling the infection and the potential role of T cells in preventing severe COVID-19.