This review article discusses the design and application of additively manufactured (AM) porous scaffolds for bone defect treatment. The study highlights the importance of scaffold design parameters such as porosity, pore size, permeability, and surface chemistry in promoting bone regeneration and osseointegration. It also explores various 3D printing techniques used to fabricate porous scaffolds with complex geometries, including triply periodic minimal surface (TPMS) structures, which mimic the hierarchical structure of human bones. The review emphasizes the role of TPMS scaffolds in enhancing cell adhesion, migration, and proliferation, as well as their ability to support vascularization and bone formation. The article also discusses the challenges and opportunities in the design and fabrication of bone scaffolds, including the need for tailored mechanical and mass transport properties. The review concludes that AM technologies offer significant potential for creating patient-specific bone substitutes with high regeneration and osseointegration capacity for repairing large bone defects. The study highlights the importance of pore geometry in bone tissue regeneration and provides a comprehensive overview of the current state of research in this field.This review article discusses the design and application of additively manufactured (AM) porous scaffolds for bone defect treatment. The study highlights the importance of scaffold design parameters such as porosity, pore size, permeability, and surface chemistry in promoting bone regeneration and osseointegration. It also explores various 3D printing techniques used to fabricate porous scaffolds with complex geometries, including triply periodic minimal surface (TPMS) structures, which mimic the hierarchical structure of human bones. The review emphasizes the role of TPMS scaffolds in enhancing cell adhesion, migration, and proliferation, as well as their ability to support vascularization and bone formation. The article also discusses the challenges and opportunities in the design and fabrication of bone scaffolds, including the need for tailored mechanical and mass transport properties. The review concludes that AM technologies offer significant potential for creating patient-specific bone substitutes with high regeneration and osseointegration capacity for repairing large bone defects. The study highlights the importance of pore geometry in bone tissue regeneration and provides a comprehensive overview of the current state of research in this field.