The article by Huveneers and Danen (2009) discusses the crosstalk between integrins, Src-family kinases (SFKs), and Rho-family GTPases in cell adhesion signaling. Integrins sense and respond to the extracellular matrix (ECM), modulating the cytoskeleton and signaling pathways. SFKs, such as FAK and Src, are crucial in coupling integrin signaling to Rho-GTPases, which control actin dynamics and cell behavior. The authors highlight recent advances in understanding how these proteins interact and regulate each other, particularly in cell adhesion, spreading, migration, and mechanotransduction. They emphasize the role of the FAK-Src complex in regulating Rho-GTPases, including the activation of Rac1 and Cdc42 for protrusive activity and the suppression of RhoA for contractility. The article also explores the involvement of these signaling pathways in physiological processes such as hemostasis, bone remodeling, phagocytosis, and tumor invasion. Additionally, it discusses the impact of mechanical forces on integrin signaling and the role of integrins in ECM assembly and angiogenesis. The authors conclude by highlighting the complexity of adhesion signaling pathways and the importance of understanding how mechanical cues are translated into biochemical changes.The article by Huveneers and Danen (2009) discusses the crosstalk between integrins, Src-family kinases (SFKs), and Rho-family GTPases in cell adhesion signaling. Integrins sense and respond to the extracellular matrix (ECM), modulating the cytoskeleton and signaling pathways. SFKs, such as FAK and Src, are crucial in coupling integrin signaling to Rho-GTPases, which control actin dynamics and cell behavior. The authors highlight recent advances in understanding how these proteins interact and regulate each other, particularly in cell adhesion, spreading, migration, and mechanotransduction. They emphasize the role of the FAK-Src complex in regulating Rho-GTPases, including the activation of Rac1 and Cdc42 for protrusive activity and the suppression of RhoA for contractility. The article also explores the involvement of these signaling pathways in physiological processes such as hemostasis, bone remodeling, phagocytosis, and tumor invasion. Additionally, it discusses the impact of mechanical forces on integrin signaling and the role of integrins in ECM assembly and angiogenesis. The authors conclude by highlighting the complexity of adhesion signaling pathways and the importance of understanding how mechanical cues are translated into biochemical changes.