Adipose-derived stem cells (ADSCs) are a promising source for tissue engineering due to their angiogenic potential and ability to differentiate into various cell types, including endothelial cells (ECs), vascular smooth muscle cells, and cardiomyocytes. These cells are easily accessible from adipose tissue, which is a major energy storage organ with regenerative potential. ADSCs can promote angiogenesis, which is crucial for tissue repair and regeneration. They are also capable of differentiating into multiple cell lineages, making them valuable for tissue engineering applications. ADSCs have been shown to enhance vascularization, improve tissue function, and support the regeneration of various tissues, including bone, cartilage, muscle, and nerve. Their ability to secrete growth factors and modulate immune responses further enhances their therapeutic potential. However, challenges remain in optimizing their use for clinical applications, including ensuring their safety, efficiency, and long-term viability. Future research should focus on understanding the molecular mechanisms underlying ADSCs' angiogenic potential and improving their differentiation and therapeutic efficacy. ADSCs hold great promise for advancing tissue engineering and regenerative medicine.Adipose-derived stem cells (ADSCs) are a promising source for tissue engineering due to their angiogenic potential and ability to differentiate into various cell types, including endothelial cells (ECs), vascular smooth muscle cells, and cardiomyocytes. These cells are easily accessible from adipose tissue, which is a major energy storage organ with regenerative potential. ADSCs can promote angiogenesis, which is crucial for tissue repair and regeneration. They are also capable of differentiating into multiple cell lineages, making them valuable for tissue engineering applications. ADSCs have been shown to enhance vascularization, improve tissue function, and support the regeneration of various tissues, including bone, cartilage, muscle, and nerve. Their ability to secrete growth factors and modulate immune responses further enhances their therapeutic potential. However, challenges remain in optimizing their use for clinical applications, including ensuring their safety, efficiency, and long-term viability. Future research should focus on understanding the molecular mechanisms underlying ADSCs' angiogenic potential and improving their differentiation and therapeutic efficacy. ADSCs hold great promise for advancing tissue engineering and regenerative medicine.