The article reviews the angiogenic potential of adipose-derived stem cells (ADSCs) and their utility in tissue engineering (TE). Adipose tissue (AT) is a significant energy storage and endocrine organ with multipotent cell types, making it an important source for stem cells. ADSCs can differentiate into various cell types, including endothelial cells (ECs), vascular smooth muscle cells, and cardiomyocytes, which are crucial for promoting angiogenesis. The article highlights the importance of functional vascular networks in engineered tissues and explores the angiogenic potential of ADSCs. It discusses the challenges and future perspectives in the clinical application of ADSCs, emphasizing the need for further research on their differentiation into ECs and the optimization of isolation and culture methods. The article also reviews the regenerative features and utility of ADSCs in various TE applications, such as adipose, bone, cartilage, muscle, corneal, nerve, liver, lung, and cardiac TE. The angiogenic potential of ADSCs is attributed to their ability to secrete growth factors, release microvesicles, and differentiate into ECs. The article concludes by emphasizing the promising role of ADSCs in regenerative medicine and the need for continued research to enhance their therapeutic applications.The article reviews the angiogenic potential of adipose-derived stem cells (ADSCs) and their utility in tissue engineering (TE). Adipose tissue (AT) is a significant energy storage and endocrine organ with multipotent cell types, making it an important source for stem cells. ADSCs can differentiate into various cell types, including endothelial cells (ECs), vascular smooth muscle cells, and cardiomyocytes, which are crucial for promoting angiogenesis. The article highlights the importance of functional vascular networks in engineered tissues and explores the angiogenic potential of ADSCs. It discusses the challenges and future perspectives in the clinical application of ADSCs, emphasizing the need for further research on their differentiation into ECs and the optimization of isolation and culture methods. The article also reviews the regenerative features and utility of ADSCs in various TE applications, such as adipose, bone, cartilage, muscle, corneal, nerve, liver, lung, and cardiac TE. The angiogenic potential of ADSCs is attributed to their ability to secrete growth factors, release microvesicles, and differentiate into ECs. The article concludes by emphasizing the promising role of ADSCs in regenerative medicine and the need for continued research to enhance their therapeutic applications.