Adipose tissue remodeling plays a critical role in energy metabolism and metabolic disorders. Adipose tissue, including white adipose tissue (WAT) and brown adipose tissue (BAT), regulates energy homeostasis by storing and releasing energy. WAT stores energy as lipids, while BAT generates heat through thermogenesis. Adipose tissue also functions as an endocrine organ, secreting adipokines that regulate systemic energy balance. In obesity, adipose tissue remodeling is associated with metabolic dysfunction, including insulin resistance and inflammation. Adipose tissue remodeling involves changes in adipocyte size and number, as well as the function of stromal vascular cells, including immune cells. Chronic overnutrition leads to uncontrolled inflammation, contributing to metabolic disorders. Adipose tissue remodeling is dynamic and reversible, with factors such as hormones and cytokines influencing the balance between pro-inflammatory and anti-inflammatory responses. Adipose tissue macrophages play a key role in remodeling, including angiogenesis, ECM remodeling, and clearance of dead adipocytes. In obesity, adipose tissue inflammation is exacerbated by the accumulation of pro-inflammatory immune cells, leading to insulin resistance and metabolic complications. Adipose tissue macrophages can be classified into M1 and M2 types, with M1 macrophages contributing to inflammation and M2 macrophages promoting resolution. The balance between these macrophage types is crucial for maintaining adipose tissue function. Adipose tissue remodeling is also influenced by factors such as diet, exercise, and genetic predisposition. Understanding the mechanisms of adipose tissue remodeling is essential for developing therapeutic strategies to treat metabolic disorders.Adipose tissue remodeling plays a critical role in energy metabolism and metabolic disorders. Adipose tissue, including white adipose tissue (WAT) and brown adipose tissue (BAT), regulates energy homeostasis by storing and releasing energy. WAT stores energy as lipids, while BAT generates heat through thermogenesis. Adipose tissue also functions as an endocrine organ, secreting adipokines that regulate systemic energy balance. In obesity, adipose tissue remodeling is associated with metabolic dysfunction, including insulin resistance and inflammation. Adipose tissue remodeling involves changes in adipocyte size and number, as well as the function of stromal vascular cells, including immune cells. Chronic overnutrition leads to uncontrolled inflammation, contributing to metabolic disorders. Adipose tissue remodeling is dynamic and reversible, with factors such as hormones and cytokines influencing the balance between pro-inflammatory and anti-inflammatory responses. Adipose tissue macrophages play a key role in remodeling, including angiogenesis, ECM remodeling, and clearance of dead adipocytes. In obesity, adipose tissue inflammation is exacerbated by the accumulation of pro-inflammatory immune cells, leading to insulin resistance and metabolic complications. Adipose tissue macrophages can be classified into M1 and M2 types, with M1 macrophages contributing to inflammation and M2 macrophages promoting resolution. The balance between these macrophage types is crucial for maintaining adipose tissue function. Adipose tissue remodeling is also influenced by factors such as diet, exercise, and genetic predisposition. Understanding the mechanisms of adipose tissue remodeling is essential for developing therapeutic strategies to treat metabolic disorders.