The study by Rupnick et al. investigates the role of angiogenesis in the growth and remodeling of adipose tissue. They hypothesized that nonneoplastic tissue growth, particularly adipose tissue, is dependent on neovascularization. Using mice from different obesity models, they treated them with anti-angiogenic agents, such as TNP-470, angiostatin, endostatin, Bay-129566, and thalidomide. The results showed that these treatments led to dose-dependent, reversible weight reduction and adipose tissue loss in mice. Vascular remodeling was evident, with decreased endothelial proliferation and increased apoptosis in treated mice compared to controls. Continuous treatment maintained mice near normal body weights without adverse effects. Metabolic adaptations, including changes in food intake, metabolic rate, and energy substrate utilization, were also observed. The study concludes that adipose tissue mass is sensitive to angiogenesis inhibitors and can be regulated by its vasculature.The study by Rupnick et al. investigates the role of angiogenesis in the growth and remodeling of adipose tissue. They hypothesized that nonneoplastic tissue growth, particularly adipose tissue, is dependent on neovascularization. Using mice from different obesity models, they treated them with anti-angiogenic agents, such as TNP-470, angiostatin, endostatin, Bay-129566, and thalidomide. The results showed that these treatments led to dose-dependent, reversible weight reduction and adipose tissue loss in mice. Vascular remodeling was evident, with decreased endothelial proliferation and increased apoptosis in treated mice compared to controls. Continuous treatment maintained mice near normal body weights without adverse effects. Metabolic adaptations, including changes in food intake, metabolic rate, and energy substrate utilization, were also observed. The study concludes that adipose tissue mass is sensitive to angiogenesis inhibitors and can be regulated by its vasculature.