This review, authored by Devagi Kanakaraju, Beverley D. Glass, and Michael Oelgemöller, focuses on the advanced oxidation processes (AOPs) used to remove pharmaceuticals from water. Pharmaceuticals, which are often detected in natural and wastewater bodies, pose significant health and environmental risks due to their persistence and toxicity. AOPs, including photo-Fenton, sonolysis, electrochemical oxidation, radiation, and ozonation, are employed to degrade these compounds using hydroxyl radicals. The review highlights recent studies that apply AOPs to degrade pharmaceuticals, discusses the effectiveness of TiO2-mediated photocatalytic treatment, and outlines the success of AOPs in various water matrices. It also provides recommendations for future research.This review, authored by Devagi Kanakaraju, Beverley D. Glass, and Michael Oelgemöller, focuses on the advanced oxidation processes (AOPs) used to remove pharmaceuticals from water. Pharmaceuticals, which are often detected in natural and wastewater bodies, pose significant health and environmental risks due to their persistence and toxicity. AOPs, including photo-Fenton, sonolysis, electrochemical oxidation, radiation, and ozonation, are employed to degrade these compounds using hydroxyl radicals. The review highlights recent studies that apply AOPs to degrade pharmaceuticals, discusses the effectiveness of TiO2-mediated photocatalytic treatment, and outlines the success of AOPs in various water matrices. It also provides recommendations for future research.