This review explores self-healing hydrogels as innovative solutions for wound management, addressing challenges such as antibiotic resistance and tailored wound care. These hydrogels exhibit promising outcomes, including accelerated wound closure and tissue regeneration. Advancements in multifunctional hydrogels with controlled drug release, antimicrobial properties, and real-time wound assessment capabilities signal a significant leap toward patient-centered treatments. However, challenges such as scalability, long-term safety evaluation, and variability in clinical outcomes persist. Future directions emphasize personalized medicine, manufacturing innovation, rigorous evaluation through clinical trials, and interdisciplinary collaboration. The manuscript highlights ongoing efforts to develop effective, adaptable, and comprehensive wound care solutions to transform medical treatments and improve patient outcomes. Keywords: wound care; self-healing hydrogels; dynamic covalent crosslinking; ionic crosslinking; functional crosslinking.This review explores self-healing hydrogels as innovative solutions for wound management, addressing challenges such as antibiotic resistance and tailored wound care. These hydrogels exhibit promising outcomes, including accelerated wound closure and tissue regeneration. Advancements in multifunctional hydrogels with controlled drug release, antimicrobial properties, and real-time wound assessment capabilities signal a significant leap toward patient-centered treatments. However, challenges such as scalability, long-term safety evaluation, and variability in clinical outcomes persist. Future directions emphasize personalized medicine, manufacturing innovation, rigorous evaluation through clinical trials, and interdisciplinary collaboration. The manuscript highlights ongoing efforts to develop effective, adaptable, and comprehensive wound care solutions to transform medical treatments and improve patient outcomes. Keywords: wound care; self-healing hydrogels; dynamic covalent crosslinking; ionic crosslinking; functional crosslinking.