Calcium phosphate (CaP) glass has gained attention as a promising material for biomedical applications due to its biocompatibility and ability to integrate with biological tissues. This review discusses the advancements in CaP glass-based devices over the past 50 years, focusing on their role in second and third-generation biomaterials. CaP glasses are used as reinforcing agents and have been studied for their ion release and drug delivery capabilities. Recent applications include soft-tissue engineering and the development of bioresorbable optical devices. Challenges and future directions highlight the potential of CaP glass in next-generation biomaterials. The review also covers the development of CaP glass-based implants, including their mechanical properties, biocompatibility, and applications in bone and tissue repair. Studies on doping CaP glass with therapeutic ions and their impact on biomedical functions are discussed, along with their use in dental and veterinary applications. The review emphasizes the promising role of CaP glass in future biomedicine, particularly in drug and gene delivery systems.Calcium phosphate (CaP) glass has gained attention as a promising material for biomedical applications due to its biocompatibility and ability to integrate with biological tissues. This review discusses the advancements in CaP glass-based devices over the past 50 years, focusing on their role in second and third-generation biomaterials. CaP glasses are used as reinforcing agents and have been studied for their ion release and drug delivery capabilities. Recent applications include soft-tissue engineering and the development of bioresorbable optical devices. Challenges and future directions highlight the potential of CaP glass in next-generation biomaterials. The review also covers the development of CaP glass-based implants, including their mechanical properties, biocompatibility, and applications in bone and tissue repair. Studies on doping CaP glass with therapeutic ions and their impact on biomedical functions are discussed, along with their use in dental and veterinary applications. The review emphasizes the promising role of CaP glass in future biomedicine, particularly in drug and gene delivery systems.