Calcium phosphate (CaP) glass has emerged as a promising material in biomedical applications, evolving from passive implants to active degradable materials, particularly in bioresorbable photonic devices. This review discusses the advancements in CaP glass-based devices over the past 50 years, focusing on their role as reinforcing agents and the studies on doping their matrices for ion release, drug, and gene delivery. Recent applications of CaP glass and fibers in soft-tissue engineering and their potential for optical quality bioresorbable devices are also discussed, along with current challenges and future directions. The review highlights the potential of CaP glass-based devices as enabling tools for implantable, bioresorbable, multifunctional biomaterials in the next generation of biomedicine. Key advancements include the development of CaP glass fibers as reinforcing agents in polymers, the antibacterial properties of doped CaP glass, and its applications in dental and veterinary fields. The review emphasizes the importance of CaP glass in advancing the field of biomaterials and its potential to revolutionize personalized and predictive medicine.Calcium phosphate (CaP) glass has emerged as a promising material in biomedical applications, evolving from passive implants to active degradable materials, particularly in bioresorbable photonic devices. This review discusses the advancements in CaP glass-based devices over the past 50 years, focusing on their role as reinforcing agents and the studies on doping their matrices for ion release, drug, and gene delivery. Recent applications of CaP glass and fibers in soft-tissue engineering and their potential for optical quality bioresorbable devices are also discussed, along with current challenges and future directions. The review highlights the potential of CaP glass-based devices as enabling tools for implantable, bioresorbable, multifunctional biomaterials in the next generation of biomedicine. Key advancements include the development of CaP glass fibers as reinforcing agents in polymers, the antibacterial properties of doped CaP glass, and its applications in dental and veterinary fields. The review emphasizes the importance of CaP glass in advancing the field of biomaterials and its potential to revolutionize personalized and predictive medicine.