This comprehensive review explores the emerging field of regenerative hydrogels and their significant impact on skin wound treatment. Regenerative hydrogels, primarily composed of water-absorbing polymers, have gained attention for their potential in wound healing, particularly for skin wounds. Their unique properties, such as excellent water retention, biocompatibility, and ability to mimic the extracellular matrix (ECM), make them well-suited for tissue regeneration. These hydrogels facilitate cell migration and proliferation, promote angiogenesis, reduce inflammation, and prevent infection, thereby accelerating the wound healing process. They are also practical due to their easy application and ability to conform to various wound shapes, including irregular or challenging areas. Additionally, regenerative hydrogels minimize scarring through tissue regeneration and contribute to pain management by creating a protective barrier. The review highlights the rational design principles that enhance the efficacy and performance of hydrogels in promoting wound healing, making them a promising approach for improving clinical outcomes in diverse clinical scenarios.This comprehensive review explores the emerging field of regenerative hydrogels and their significant impact on skin wound treatment. Regenerative hydrogels, primarily composed of water-absorbing polymers, have gained attention for their potential in wound healing, particularly for skin wounds. Their unique properties, such as excellent water retention, biocompatibility, and ability to mimic the extracellular matrix (ECM), make them well-suited for tissue regeneration. These hydrogels facilitate cell migration and proliferation, promote angiogenesis, reduce inflammation, and prevent infection, thereby accelerating the wound healing process. They are also practical due to their easy application and ability to conform to various wound shapes, including irregular or challenging areas. Additionally, regenerative hydrogels minimize scarring through tissue regeneration and contribute to pain management by creating a protective barrier. The review highlights the rational design principles that enhance the efficacy and performance of hydrogels in promoting wound healing, making them a promising approach for improving clinical outcomes in diverse clinical scenarios.