This review explores the role of regenerative hydrogels in skin wound treatment, highlighting their unique properties and benefits. Regenerative hydrogels, composed mainly of water-absorbing polymers, are well-suited for tissue regeneration due to their excellent water retention, which creates a moist wound environment conducive to healing. They support cell migration and proliferation, act as a supportive scaffold for cell growth, and can be engineered for controlled drug release, enhancing wound healing by promoting angiogenesis, reducing inflammation, and preventing infection. Their flexibility and ability to conform to wound contours ensure optimal tissue contact, improving treatment effectiveness. Additionally, some hydrogels have inherent antimicrobial properties, aiding in infection prevention. The review discusses the characteristics of skin wounds, the healing process, and the applications of hydrogels in wound regeneration. It also covers the chemical composition and mechanisms of action of regenerative hydrogels, including their role in wound healing, the use of reactive oxygen species (ROS) in the healing process, and the incorporation of antioxidant compounds such as natural polyphenols, polysaccharides, amino acids, synthetic polymers, and novel metallic nanomaterials. The review emphasizes the potential of regenerative hydrogels in improving skin wound healing outcomes across diverse clinical scenarios.This review explores the role of regenerative hydrogels in skin wound treatment, highlighting their unique properties and benefits. Regenerative hydrogels, composed mainly of water-absorbing polymers, are well-suited for tissue regeneration due to their excellent water retention, which creates a moist wound environment conducive to healing. They support cell migration and proliferation, act as a supportive scaffold for cell growth, and can be engineered for controlled drug release, enhancing wound healing by promoting angiogenesis, reducing inflammation, and preventing infection. Their flexibility and ability to conform to wound contours ensure optimal tissue contact, improving treatment effectiveness. Additionally, some hydrogels have inherent antimicrobial properties, aiding in infection prevention. The review discusses the characteristics of skin wounds, the healing process, and the applications of hydrogels in wound regeneration. It also covers the chemical composition and mechanisms of action of regenerative hydrogels, including their role in wound healing, the use of reactive oxygen species (ROS) in the healing process, and the incorporation of antioxidant compounds such as natural polyphenols, polysaccharides, amino acids, synthetic polymers, and novel metallic nanomaterials. The review emphasizes the potential of regenerative hydrogels in improving skin wound healing outcomes across diverse clinical scenarios.