This review explores recent advancements in hydrogel design for articular cartilage regeneration (CR). Articular cartilage (AC) defects are common and can lead to joint breakdown, necessitating effective regeneration. Hydrogels, due to their tunable properties, are promising for CR. Key design parameters include hydrogel components, mechanical properties, biodegradability, structural design, and integration with native tissue. Stratified-structural hydrogels that mimic native cartilage and the impact of environmental stimuli on regeneration are discussed. Recent advances highlight the importance of hydrogel properties such as stiffness, elasticity, and load-bearing capacity in mimicking natural cartilage. Biodegradability is crucial for maintaining structural integrity while allowing cell infiltration. Porosity and interconnectivity are essential for cellular infiltration, nutrient diffusion, and waste removal. Integration with native tissue is vital for long-term functionality. Injectable hydrogels offer advantages in filling irregular defects and enabling minimally invasive procedures. The review emphasizes the need for hydrogels that can support cell growth, promote chondrogenesis, and integrate with surrounding tissue. Future research should focus on optimizing hydrogel properties to enhance cartilage repair and meet clinical needs.This review explores recent advancements in hydrogel design for articular cartilage regeneration (CR). Articular cartilage (AC) defects are common and can lead to joint breakdown, necessitating effective regeneration. Hydrogels, due to their tunable properties, are promising for CR. Key design parameters include hydrogel components, mechanical properties, biodegradability, structural design, and integration with native tissue. Stratified-structural hydrogels that mimic native cartilage and the impact of environmental stimuli on regeneration are discussed. Recent advances highlight the importance of hydrogel properties such as stiffness, elasticity, and load-bearing capacity in mimicking natural cartilage. Biodegradability is crucial for maintaining structural integrity while allowing cell infiltration. Porosity and interconnectivity are essential for cellular infiltration, nutrient diffusion, and waste removal. Integration with native tissue is vital for long-term functionality. Injectable hydrogels offer advantages in filling irregular defects and enabling minimally invasive procedures. The review emphasizes the need for hydrogels that can support cell growth, promote chondrogenesis, and integrate with surrounding tissue. Future research should focus on optimizing hydrogel properties to enhance cartilage repair and meet clinical needs.