This comprehensive review explores the forefront of nanohybrid materials, focusing on the integration of coordination materials in various applications, particularly in the development of flexible solar cells. Coordination material-based nanohybrids, characterized by their unique properties and multifunctionality, have gained significant attention in fields such as catalysis, sensing, drug delivery, and energy storage. The review investigates the synthesis methods, properties, and potential applications of these nanohybrids, emphasizing their versatility in materials science. Additionally, the integration of coordination nanohybrids in perovskite solar cells (PSCs) is discussed, highlighting their ability to enhance the performance and stability of next-generation photovoltaic devices. The review also covers the synthesis of luminescent nanohybrids for bioimaging purposes and the development of layered, two-dimensional (2D) material-based nanostructured hybrids for energy storage and conversion. The exploration further includes the synthesis of conductive polymer nanostructures for drug delivery systems and the cutting-edge realm of flexible solar cells, emphasizing their adaptability and lightweight design. Through a systematic examination of these diverse nanohybrid materials, the review sheds light on the current state of the art, challenges, and prospects, providing valuable insights for researchers and practitioners in materials science, nanotechnology, and renewable energy.This comprehensive review explores the forefront of nanohybrid materials, focusing on the integration of coordination materials in various applications, particularly in the development of flexible solar cells. Coordination material-based nanohybrids, characterized by their unique properties and multifunctionality, have gained significant attention in fields such as catalysis, sensing, drug delivery, and energy storage. The review investigates the synthesis methods, properties, and potential applications of these nanohybrids, emphasizing their versatility in materials science. Additionally, the integration of coordination nanohybrids in perovskite solar cells (PSCs) is discussed, highlighting their ability to enhance the performance and stability of next-generation photovoltaic devices. The review also covers the synthesis of luminescent nanohybrids for bioimaging purposes and the development of layered, two-dimensional (2D) material-based nanostructured hybrids for energy storage and conversion. The exploration further includes the synthesis of conductive polymer nanostructures for drug delivery systems and the cutting-edge realm of flexible solar cells, emphasizing their adaptability and lightweight design. Through a systematic examination of these diverse nanohybrid materials, the review sheds light on the current state of the art, challenges, and prospects, providing valuable insights for researchers and practitioners in materials science, nanotechnology, and renewable energy.