31 May 2024 | Zahra-Sadat Razavi, Madjid Soltani, Golnaz Mahmoudvand, Simin Farokhi, Arian Karimi-Rouzbahani, Bahareh Farasati-Far, Samaneh Tahmasebi-Ghorabi, Hamidreza Pazoki-Toroudi and Hamed Afkhami
The article "Advancements in Tissue Engineering for Cardiovascular Health: A Biomedical Engineering Perspective" by Zahra-Sadat Razavi et al. explores the advancements in tissue engineering, particularly focusing on cardiac tissue engineering. The authors highlight the significant role of biomaterial scaffolds in addressing the challenges posed by myocardial infarction (MI) and heart failure (HF). They discuss the limitations of the adult heart's regenerative capacity and the need for alternative treatments, such as cardiac tissue engineering. The review covers the integration of bio-functional materials, the use of biomaterial scaffolds, and the application of stem cells in cardiac tissue engineering. Key topics include the development of biomaterial scaffolds, their properties, and their impact on cell adhesion, migration, and differentiation. The article also delves into advanced techniques such as 3D bioprinting, microfluidics, and scaffold-free bioprinting, emphasizing their potential in creating more realistic and functional cardiac tissues. Additionally, the selection of materials for cardiac tissue engineering scaffolds is discussed, including the advantages and challenges of using synthetic and natural polymers. The authors aim to provide a comprehensive overview of the current landscape in cardiac tissue engineering, highlighting the promising avenues for future advancements.The article "Advancements in Tissue Engineering for Cardiovascular Health: A Biomedical Engineering Perspective" by Zahra-Sadat Razavi et al. explores the advancements in tissue engineering, particularly focusing on cardiac tissue engineering. The authors highlight the significant role of biomaterial scaffolds in addressing the challenges posed by myocardial infarction (MI) and heart failure (HF). They discuss the limitations of the adult heart's regenerative capacity and the need for alternative treatments, such as cardiac tissue engineering. The review covers the integration of bio-functional materials, the use of biomaterial scaffolds, and the application of stem cells in cardiac tissue engineering. Key topics include the development of biomaterial scaffolds, their properties, and their impact on cell adhesion, migration, and differentiation. The article also delves into advanced techniques such as 3D bioprinting, microfluidics, and scaffold-free bioprinting, emphasizing their potential in creating more realistic and functional cardiac tissues. Additionally, the selection of materials for cardiac tissue engineering scaffolds is discussed, including the advantages and challenges of using synthetic and natural polymers. The authors aim to provide a comprehensive overview of the current landscape in cardiac tissue engineering, highlighting the promising avenues for future advancements.