Advances and applications of nanoparticles in cancer therapy A research team led by Dr. Xianzhou Huang from the Department of Biotherapy, Cancer Center, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, has published a review in the journal MedComm – Oncology, highlighting the potential of nanoparticles as delivery systems in cancer treatment. The review discusses the rapid development of various nanoparticle types, including micelles, liposomes, polymeric nanoparticles, dendrimer nanoparticles, polymersomes, protein nanoparticles, inorganic nanoparticles, exosomes, biomimetic nanoparticles, molecularly imprinted nanoparticles, and hybrid nanoparticles. These nanoparticles are used in diverse therapeutic approaches, such as chemotherapy, radiotherapy, phototherapy, immunotherapy, and gene therapy, as well as combination therapies. Nanoparticles offer advantages such as long-circulation time, targeting abilities, and responsiveness to various biological factors, enabling precise drug delivery and function. A notable example is the nano-CRISPR scaffold (Nano-CD), which co-delivers cisplatin and CRISPR/dCas9 plasmid to induce pyroptosis in tumor cells. The review emphasizes the versatility and modifiability of nanotechnology in overcoming cancer treatment challenges and creating new opportunities for cancer therapy. The authors expect that ongoing research will further advance nanoparticle-based cancer treatments, making them common clinical approaches in the future. The study underscores the importance of continued efforts in this field to shift the paradigm of cancer therapy. More information is available in the original paper.Advances and applications of nanoparticles in cancer therapy A research team led by Dr. Xianzhou Huang from the Department of Biotherapy, Cancer Center, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, has published a review in the journal MedComm – Oncology, highlighting the potential of nanoparticles as delivery systems in cancer treatment. The review discusses the rapid development of various nanoparticle types, including micelles, liposomes, polymeric nanoparticles, dendrimer nanoparticles, polymersomes, protein nanoparticles, inorganic nanoparticles, exosomes, biomimetic nanoparticles, molecularly imprinted nanoparticles, and hybrid nanoparticles. These nanoparticles are used in diverse therapeutic approaches, such as chemotherapy, radiotherapy, phototherapy, immunotherapy, and gene therapy, as well as combination therapies. Nanoparticles offer advantages such as long-circulation time, targeting abilities, and responsiveness to various biological factors, enabling precise drug delivery and function. A notable example is the nano-CRISPR scaffold (Nano-CD), which co-delivers cisplatin and CRISPR/dCas9 plasmid to induce pyroptosis in tumor cells. The review emphasizes the versatility and modifiability of nanotechnology in overcoming cancer treatment challenges and creating new opportunities for cancer therapy. The authors expect that ongoing research will further advance nanoparticle-based cancer treatments, making them common clinical approaches in the future. The study underscores the importance of continued efforts in this field to shift the paradigm of cancer therapy. More information is available in the original paper.