The article reviews the advancements and applications of nanoparticles in cancer therapy, highlighting their potential to enhance various therapeutic approaches. Developed nanoparticles, such as micelles, liposomes, polymeric nanoparticles, and hybrid nanoparticles, offer versatile and targeted delivery systems for drugs. These nanoparticles can be designed to circulate longer, target specific cells, and respond to various biological conditions, making them effective in combination therapies. A notable example is the Nano-CD, which co-delivers cisplatin and CRISPR/dCas9 plasmid to induce pyroptosis in tumor cells. The review emphasizes the growing understanding of the challenges and opportunities in using nanoparticles for cancer therapy and looks forward to their widespread adoption in clinical practice.The article reviews the advancements and applications of nanoparticles in cancer therapy, highlighting their potential to enhance various therapeutic approaches. Developed nanoparticles, such as micelles, liposomes, polymeric nanoparticles, and hybrid nanoparticles, offer versatile and targeted delivery systems for drugs. These nanoparticles can be designed to circulate longer, target specific cells, and respond to various biological conditions, making them effective in combination therapies. A notable example is the Nano-CD, which co-delivers cisplatin and CRISPR/dCas9 plasmid to induce pyroptosis in tumor cells. The review emphasizes the growing understanding of the challenges and opportunities in using nanoparticles for cancer therapy and looks forward to their widespread adoption in clinical practice.