This review discusses advancements in antimicrobial coatings for preventing infections of head-related implantable medical devices. Medical devices, such as dental implants, cochlear implants, contact lenses, and sinus stents, are prone to microbial colonization and biofilm formation, which can lead to serious infections and implant failure. Traditional antibiotic treatments are limited by systemic side effects, toxicity, and the development of drug-resistant bacteria. Antimicrobial coatings offer a promising solution by providing localized, targeted antimicrobial action that reduces the risk of infection and enhances the biocompatibility of implants. The review highlights various techniques for modifying medical device surfaces to prevent microbial attachment, including mechanical, physical, chemical, and biological methods. These techniques aim to create surfaces that resist bacterial adhesion and biofilm formation. Antimicrobial coatings can be made from a variety of materials, including polymers, ceramics, and metals, each with unique properties that contribute to their effectiveness against bacteria. Drug release from coatings is a critical aspect of antimicrobial strategies, as it allows for controlled and sustained delivery of antimicrobial agents. Different stimuli, such as pH, temperature, and enzymatic activity, can trigger the release of drugs from coatings, ensuring that the appropriate amount of antimicrobial agent is delivered at the right time and location. This targeted approach minimizes systemic side effects and reduces the risk of antibiotic resistance. The review also discusses specific applications of antimicrobial coatings on various head-related medical devices. For example, dental implants benefit from coatings that prevent bacterial colonization and promote osseointegration. Ocular prostheses and contact lenses can be coated with antimicrobial agents to reduce the risk of infection. Cochlear implants and sinus stents are also discussed, with a focus on the use of antimicrobial coatings to prevent biofilm formation and infection. Overall, the review emphasizes the importance of antimicrobial coatings in reducing the risk of infections associated with implantable medical devices and highlights the potential of these coatings to improve patient outcomes by preventing implant-associated infections.This review discusses advancements in antimicrobial coatings for preventing infections of head-related implantable medical devices. Medical devices, such as dental implants, cochlear implants, contact lenses, and sinus stents, are prone to microbial colonization and biofilm formation, which can lead to serious infections and implant failure. Traditional antibiotic treatments are limited by systemic side effects, toxicity, and the development of drug-resistant bacteria. Antimicrobial coatings offer a promising solution by providing localized, targeted antimicrobial action that reduces the risk of infection and enhances the biocompatibility of implants. The review highlights various techniques for modifying medical device surfaces to prevent microbial attachment, including mechanical, physical, chemical, and biological methods. These techniques aim to create surfaces that resist bacterial adhesion and biofilm formation. Antimicrobial coatings can be made from a variety of materials, including polymers, ceramics, and metals, each with unique properties that contribute to their effectiveness against bacteria. Drug release from coatings is a critical aspect of antimicrobial strategies, as it allows for controlled and sustained delivery of antimicrobial agents. Different stimuli, such as pH, temperature, and enzymatic activity, can trigger the release of drugs from coatings, ensuring that the appropriate amount of antimicrobial agent is delivered at the right time and location. This targeted approach minimizes systemic side effects and reduces the risk of antibiotic resistance. The review also discusses specific applications of antimicrobial coatings on various head-related medical devices. For example, dental implants benefit from coatings that prevent bacterial colonization and promote osseointegration. Ocular prostheses and contact lenses can be coated with antimicrobial agents to reduce the risk of infection. Cochlear implants and sinus stents are also discussed, with a focus on the use of antimicrobial coatings to prevent biofilm formation and infection. Overall, the review emphasizes the importance of antimicrobial coatings in reducing the risk of infections associated with implantable medical devices and highlights the potential of these coatings to improve patient outcomes by preventing implant-associated infections.