This review article focuses on the advancements in biointegrated flexible and stretchable optoelectronic devices for cardiac healthcare. The authors highlight the challenges posed by the mechanical mismatch between rigid optoelectronic devices and biological tissues, emphasizing the need for flexible and stretchable designs to achieve seamless integration. They discuss various strategies for achieving stretchability, including structural engineering (buckling, island-bridge, and kirigami structures) and intrinsic stretchability through backbone engineering and side-chain modification. The article also covers interface adhesion design, such as irreversible covalent, dynamic covalent, and noncovalent adhesives, to ensure strong and stable contact with biological tissues. Additionally, it explores encapsulation design for both long-term and transient applications, ensuring protection from biofluid erosion and biocompatibility. The practical applications of these devices in cardiac physiological monitoring, optogenetics, and nongenetic stimulation are discussed, emphasizing their potential in providing continuous, real-time, and personalized cardiac healthcare. The review concludes with an outlook on the challenges and future directions in the development of biointegrated flexible and stretchable optoelectronic devices for cardiac healthcare.This review article focuses on the advancements in biointegrated flexible and stretchable optoelectronic devices for cardiac healthcare. The authors highlight the challenges posed by the mechanical mismatch between rigid optoelectronic devices and biological tissues, emphasizing the need for flexible and stretchable designs to achieve seamless integration. They discuss various strategies for achieving stretchability, including structural engineering (buckling, island-bridge, and kirigami structures) and intrinsic stretchability through backbone engineering and side-chain modification. The article also covers interface adhesion design, such as irreversible covalent, dynamic covalent, and noncovalent adhesives, to ensure strong and stable contact with biological tissues. Additionally, it explores encapsulation design for both long-term and transient applications, ensuring protection from biofluid erosion and biocompatibility. The practical applications of these devices in cardiac physiological monitoring, optogenetics, and nongenetic stimulation are discussed, emphasizing their potential in providing continuous, real-time, and personalized cardiac healthcare. The review concludes with an outlook on the challenges and future directions in the development of biointegrated flexible and stretchable optoelectronic devices for cardiac healthcare.