The paper "Advances in the Application of Transition-Metal Composite Nanozymes in the Field of Biomedicine" by Huixin Wang et al. reviews the development and applications of composite nanozymes, which are materials that mimic the catalytic activity of enzymes, particularly peroxidase. These nanozymes are designed to function in harsh environments, addressing the limitations of natural enzymes. The study focuses on composite nanozymes made from noble metals like gold (Au), silver (Ag), and platinum (Pt) and other transition metals, highlighting their potential in biomedical applications such as glucose detection, cancer cell detection, tumor treatment, and antibacterial therapy. Key findings include: 1. **Peroxidase-Mimicking Activity**: Transition metal nanoparticles, when composite with other materials, exhibit excellent peroxidase-like activity, enabling them to mimic the catalytic properties of natural enzymes. 2. **Biomedical Applications**: - **Glucose Detection**: Ag-, Au-, and Pt-based composite nanozymes have been used in cascade reactions for glucose detection, with Pt-based materials showing high sensitivity. - **Antibacterial Applications**: Ag-based composite nanozymes can inhibit bacteria through the synergistic effect of Ag ions and •OH radicals. Au- and Pt-based nanozymes can also be synergistically antimicrobial when exposed to laser irradiation. - **Tumor Cell Inhibition**: Pt-based nanomaterials and other transition metal nanomaterials are used in tumor cell therapy, often employing laser irradiation to convert oxygen into reactive oxygen species for effective tumor treatment. 3. **Other Transition-Metal Composite Nanozymes**: The paper also discusses the development of composite nanozymes from other transition metals, which, while less expensive to prepare, have lower mimetic enzyme activity. These nanozymes can improve simulated enzyme activity through synergistic interactions between metals. The authors conclude that while the development of transition-metal composite nanozymes remains a challenge, their applications in various biomedical fields show significant promise. The paper emphasizes the need for further research to improve biocompatibility, reduce production costs, and enhance mimetic enzyme activity.The paper "Advances in the Application of Transition-Metal Composite Nanozymes in the Field of Biomedicine" by Huixin Wang et al. reviews the development and applications of composite nanozymes, which are materials that mimic the catalytic activity of enzymes, particularly peroxidase. These nanozymes are designed to function in harsh environments, addressing the limitations of natural enzymes. The study focuses on composite nanozymes made from noble metals like gold (Au), silver (Ag), and platinum (Pt) and other transition metals, highlighting their potential in biomedical applications such as glucose detection, cancer cell detection, tumor treatment, and antibacterial therapy. Key findings include: 1. **Peroxidase-Mimicking Activity**: Transition metal nanoparticles, when composite with other materials, exhibit excellent peroxidase-like activity, enabling them to mimic the catalytic properties of natural enzymes. 2. **Biomedical Applications**: - **Glucose Detection**: Ag-, Au-, and Pt-based composite nanozymes have been used in cascade reactions for glucose detection, with Pt-based materials showing high sensitivity. - **Antibacterial Applications**: Ag-based composite nanozymes can inhibit bacteria through the synergistic effect of Ag ions and •OH radicals. Au- and Pt-based nanozymes can also be synergistically antimicrobial when exposed to laser irradiation. - **Tumor Cell Inhibition**: Pt-based nanomaterials and other transition metal nanomaterials are used in tumor cell therapy, often employing laser irradiation to convert oxygen into reactive oxygen species for effective tumor treatment. 3. **Other Transition-Metal Composite Nanozymes**: The paper also discusses the development of composite nanozymes from other transition metals, which, while less expensive to prepare, have lower mimetic enzyme activity. These nanozymes can improve simulated enzyme activity through synergistic interactions between metals. The authors conclude that while the development of transition-metal composite nanozymes remains a challenge, their applications in various biomedical fields show significant promise. The paper emphasizes the need for further research to improve biocompatibility, reduce production costs, and enhance mimetic enzyme activity.