This systematic review aims to explore the management of orofacial discomfort following a cancer diagnosis in the head and neck region, focusing on postoperative pain control in oral cancer patients. The review was conducted using databases such as PubMed, Scopus, and Web of Science, with a focus on open-access research, including randomized clinical trials, retrospective studies, case-control studies, and prospective studies. The inclusion criteria were studies written in English, while animal studies, in vitro studies, off-topic studies, and non-English language publications were excluded. The review highlights the persistent use of opioids in the postoperative phase, the efficacy of adjuvant drugs like gabapentin, and the importance of a multimodal approach to pain management. It emphasizes the need for personalized pain management, recognizing individual pain perception and tailoring interventions accordingly. The review also discusses the integration of pharmacological and non-pharmacological strategies for comprehensive pain management. Key findings include the high prevalence of pain in oral cancer patients, the effectiveness of non-steroidal anti-inflammatory drugs (NSAIDs) and opioids in managing pain, and the potential benefits of adjuvant therapies such as dexmedetomidine. The review also highlights the importance of preemptive analgesia and the use of multimodal approaches to enhance pain control. Despite the valuable insights provided, the review acknowledges limitations, including the limited availability of studies, language bias, heterogeneity in study designs, and potential publication bias. The review concludes by emphasizing the need for further research to establish more robust methodologies and diverse participant populations, aiming to deepen the understanding of oral cancer pain management and refine evidence-based practices.This systematic review aims to explore the management of orofacial discomfort following a cancer diagnosis in the head and neck region, focusing on postoperative pain control in oral cancer patients. The review was conducted using databases such as PubMed, Scopus, and Web of Science, with a focus on open-access research, including randomized clinical trials, retrospective studies, case-control studies, and prospective studies. The inclusion criteria were studies written in English, while animal studies, in vitro studies, off-topic studies, and non-English language publications were excluded. The review highlights the persistent use of opioids in the postoperative phase, the efficacy of adjuvant drugs like gabapentin, and the importance of a multimodal approach to pain management. It emphasizes the need for personalized pain management, recognizing individual pain perception and tailoring interventions accordingly. The review also discusses the integration of pharmacological and non-pharmacological strategies for comprehensive pain management. Key findings include the high prevalence of pain in oral cancer patients, the effectiveness of non-steroidal anti-inflammatory drugs (NSAIDs) and opioids in managing pain, and the potential benefits of adjuvant therapies such as dexmedetomidine. The review also highlights the importance of preemptive analgesia and the use of multimodal approaches to enhance pain control. Despite the valuable insights provided, the review acknowledges limitations, including the limited availability of studies, language bias, heterogeneity in study designs, and potential publication bias. The review concludes by emphasizing the need for further research to establish more robust methodologies and diverse participant populations, aiming to deepen the understanding of oral cancer pain management and refine evidence-based practices.