This systematic review explores postoperative pain management in oral cancer patients, emphasizing the need for personalized, multimodal approaches. The study analyzed 2933 publications from PubMed, Scopus, and Web of Science, selecting 11 eligible studies. Key findings include the persistent use of opioids in postoperative care, the efficacy of adjuvant drugs like gabapentin, and the benefits of multimodal strategies combining pharmacological and non-pharmacological methods. The review highlights the importance of individualized pain management, considering patient-specific factors such as pain perception and preoperative opioid use. It also discusses the role of non-opioid analgesics, such as NSAIDs, and the potential of adjuvant therapies in improving outcomes. The study underscores the need for standardized methodologies and diverse participant populations in future research. Limitations include the exclusion of non-English studies and the heterogeneity of included studies. Overall, the review advocates for a comprehensive, patient-centered approach to postoperative pain management in oral cancer patients.This systematic review explores postoperative pain management in oral cancer patients, emphasizing the need for personalized, multimodal approaches. The study analyzed 2933 publications from PubMed, Scopus, and Web of Science, selecting 11 eligible studies. Key findings include the persistent use of opioids in postoperative care, the efficacy of adjuvant drugs like gabapentin, and the benefits of multimodal strategies combining pharmacological and non-pharmacological methods. The review highlights the importance of individualized pain management, considering patient-specific factors such as pain perception and preoperative opioid use. It also discusses the role of non-opioid analgesics, such as NSAIDs, and the potential of adjuvant therapies in improving outcomes. The study underscores the need for standardized methodologies and diverse participant populations in future research. Limitations include the exclusion of non-English studies and the heterogeneity of included studies. Overall, the review advocates for a comprehensive, patient-centered approach to postoperative pain management in oral cancer patients.